Abstract
We report the results of our study into a series of 3,5-dibrominated derivatives of esters of 4- [(aminosulfonyl)oxy]benzoate as potential inhibitors of estrone sulfatase (ES). The results suggest that the compounds are weak inhibitors as a result of the incorporation of the bromine atoms which reduce the stability of the compound.
Keywords: Estrone sulfatase, Inhibition, Breast cancer pKa, Dibrominated, Benzoic acid esters
Letters in Drug Design & Discovery
Title: Synthesis and In Vitro Biochemical Evaluation of a Series of Compounds as Potential Inhibitors of Estrone Sulfatase (ES) and the Role of pKa in both the Synthesis and the Inhibitory Activity of the Potential Inhibitors
Volume: 4 Issue: 6
Author(s): Caroline P. Owen, Mijal Patel, Chirag K Patel, Tim Cartledge and Sabbir Ahmed
Affiliation:
Keywords: Estrone sulfatase, Inhibition, Breast cancer pKa, Dibrominated, Benzoic acid esters
Abstract: We report the results of our study into a series of 3,5-dibrominated derivatives of esters of 4- [(aminosulfonyl)oxy]benzoate as potential inhibitors of estrone sulfatase (ES). The results suggest that the compounds are weak inhibitors as a result of the incorporation of the bromine atoms which reduce the stability of the compound.
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Caroline P. Owen , Mijal Patel , Chirag K Patel , Tim Cartledge and Sabbir Ahmed , Synthesis and In Vitro Biochemical Evaluation of a Series of Compounds as Potential Inhibitors of Estrone Sulfatase (ES) and the Role of pKa in both the Synthesis and the Inhibitory Activity of the Potential Inhibitors, Letters in Drug Design & Discovery 2007; 4 (6) . https://dx.doi.org/10.2174/157018007781387773
DOI https://dx.doi.org/10.2174/157018007781387773 |
Print ISSN 1570-1808 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-628X |
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