Abstract
The transport mechanism-based molecular design strategy would provide an effective tool for rationalized chemotherapy against tumors. To develop a platform for molecular modeling to circumvent multidrug resistance, we established new methods of high-speed screening for human ABCG2-drug interactions, quantitative structure-activity relationship (QSAR) analysis, and quantum chemical calculation for lead optimization.
Keywords: ABC transporter, ABCG2, BCRP, camptothecin, high-throughput screening, irinotecan, multidrug resistance, QSAR analysis
Mini-Reviews in Medicinal Chemistry
Title: High-Speed Screening and Quantitative SAR Analysis of Human ABC Transporter ABCG2 for Molecular Modeling of Anticancer Drugs to Circumvent Multidrug Resistance
Volume: 7 Issue: 10
Author(s): H. Saito, H. Hirano and T. Ishikawa
Affiliation:
Keywords: ABC transporter, ABCG2, BCRP, camptothecin, high-throughput screening, irinotecan, multidrug resistance, QSAR analysis
Abstract: The transport mechanism-based molecular design strategy would provide an effective tool for rationalized chemotherapy against tumors. To develop a platform for molecular modeling to circumvent multidrug resistance, we established new methods of high-speed screening for human ABCG2-drug interactions, quantitative structure-activity relationship (QSAR) analysis, and quantum chemical calculation for lead optimization.
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Saito H., Hirano H. and Ishikawa T., High-Speed Screening and Quantitative SAR Analysis of Human ABC Transporter ABCG2 for Molecular Modeling of Anticancer Drugs to Circumvent Multidrug Resistance, Mini-Reviews in Medicinal Chemistry 2007; 7 (10) . https://dx.doi.org/10.2174/138955707782110169
DOI https://dx.doi.org/10.2174/138955707782110169 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
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