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Letters in Organic Chemistry

Editor-in-Chief

ISSN (Print): 1570-1786
ISSN (Online): 1875-6255

A Very Short and Efficient Synthesis of Preclamol

Author(s): Arnault de Filippis, Domingo Gomez Pardo and Janine Cossy

Volume 2, Issue 2, 2005

Page: [136 - 138] Pages: 3

DOI: 10.2174/1570178053202883

Price: $65

Abstract

A very short and efficient synthesis of preclamol is described. The key step is the palladiumcatalysed arylation of the zinc enolate of N-propyl-2-piperidinone.

Keywords: preclamol, arylations, lactams, palladium, zinc, coupling reaction


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