Abstract
Both enveloped and non-enveloped viruses from different families may use heparan sulfates (HS) to bind to and / or enter into their host cells. The interactions between viruses and HS can be inhibited by a novel class of antiviral compounds, the N,N-bisheteryl derivatives of 3,12-diaza-6,9-diazoniadispiro(5,2,5,2) hexadecane which bind to specific structural moieties of HS. By this way these compounds block adsorption of viruses that use HS as their initial interaction site with the cell, e.g. herpes simplex viruses, cytomegalovirus, respiratory syncytial virus, and human immunodeficiency viruses.
Keywords: receptor, heparan sulfate, proteoglycans, dispirotripiperazine, virus, antiviral
Letters in Drug Design & Discovery
Title: Novel Opportunities to Study and Block Interactions between Viruses and Cell Surface Heparan Sulfates by using Dispirotripiperazines
Volume: 1 Issue: 4
Author(s): M. Schmidtke, P. Wutzler and V. Makarov
Affiliation:
Keywords: receptor, heparan sulfate, proteoglycans, dispirotripiperazine, virus, antiviral
Abstract: Both enveloped and non-enveloped viruses from different families may use heparan sulfates (HS) to bind to and / or enter into their host cells. The interactions between viruses and HS can be inhibited by a novel class of antiviral compounds, the N,N-bisheteryl derivatives of 3,12-diaza-6,9-diazoniadispiro(5,2,5,2) hexadecane which bind to specific structural moieties of HS. By this way these compounds block adsorption of viruses that use HS as their initial interaction site with the cell, e.g. herpes simplex viruses, cytomegalovirus, respiratory syncytial virus, and human immunodeficiency viruses.
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Cite this article as:
Schmidtke M., Wutzler P. and Makarov V., Novel Opportunities to Study and Block Interactions between Viruses and Cell Surface Heparan Sulfates by using Dispirotripiperazines, Letters in Drug Design & Discovery 2004; 1 (4) . https://dx.doi.org/10.2174/1570180043398768
DOI https://dx.doi.org/10.2174/1570180043398768 |
Print ISSN 1570-1808 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-628X |
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