Abstract
The review presents three hypotheses concerning the amino acid complementarity: 1) the Mekler-Blalock antisense hypothesis; 2) the Root-Bernstein approach based on stereochemical complementarity of amino acids and antiamino acids coded by anticodons read in parallel with the coding DNA strand; 3) Siemion hypothesis resulting from the periodicity of the genetic code. The current state of knowledge as well as the results of the implementations of these hypotheses are compared. A special attention is given to Root-Bernstein and Siemion hypotheses, which differ in only few points of the complementarity prediction. We describe methods of investigation of peptide - antipeptide pairing, including circular dichroism, mass spectrometry, affinity chromatography and other techniques. The biological applications of complementarity principle are considered, such as search for bioeffector - bioreceptor interaction systems, the influence of peptide - antipeptide pairing on the activity of peptide hormones, and the application of antipeptides in immunochemistry. The possible role of amino acid - anti-amino acid interactions in the formation of the spatial structures of peptides, proteins and protein complexes is discussed. Such problems as the pairing preferences of protein - protein interfaces, the role of the pairing in the creation of disulfide bonds and the possible appearance of such interactions in β-structure are also examined. The main intention of the paper is to bring the complementarity problem to the attention of the scientific community, as a possible tool in proteomics, molecular design and molecular recognition.
Keywords: complementary peptides, antisense peptides, antipeptides, antiidiotypic antibodies, hydropathic complementarity
Current Protein & Peptide Science
Title: The Problem of Amino Acid Complementarity and Antisense Peptides
Volume: 5 Issue: 6
Author(s): Ignacy Z. Siemion, Marek Cebrat and Alicja Kluczyk
Affiliation:
Keywords: complementary peptides, antisense peptides, antipeptides, antiidiotypic antibodies, hydropathic complementarity
Abstract: The review presents three hypotheses concerning the amino acid complementarity: 1) the Mekler-Blalock antisense hypothesis; 2) the Root-Bernstein approach based on stereochemical complementarity of amino acids and antiamino acids coded by anticodons read in parallel with the coding DNA strand; 3) Siemion hypothesis resulting from the periodicity of the genetic code. The current state of knowledge as well as the results of the implementations of these hypotheses are compared. A special attention is given to Root-Bernstein and Siemion hypotheses, which differ in only few points of the complementarity prediction. We describe methods of investigation of peptide - antipeptide pairing, including circular dichroism, mass spectrometry, affinity chromatography and other techniques. The biological applications of complementarity principle are considered, such as search for bioeffector - bioreceptor interaction systems, the influence of peptide - antipeptide pairing on the activity of peptide hormones, and the application of antipeptides in immunochemistry. The possible role of amino acid - anti-amino acid interactions in the formation of the spatial structures of peptides, proteins and protein complexes is discussed. Such problems as the pairing preferences of protein - protein interfaces, the role of the pairing in the creation of disulfide bonds and the possible appearance of such interactions in β-structure are also examined. The main intention of the paper is to bring the complementarity problem to the attention of the scientific community, as a possible tool in proteomics, molecular design and molecular recognition.
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Cite this article as:
Siemion Z. Ignacy, Cebrat Marek and Kluczyk Alicja, The Problem of Amino Acid Complementarity and Antisense Peptides, Current Protein & Peptide Science 2004; 5 (6) . https://dx.doi.org/10.2174/1389203043379413
DOI https://dx.doi.org/10.2174/1389203043379413 |
Print ISSN 1389-2037 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5550 |
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