Abstract
The selectins are a family of cell-adhesion proteins that mediate the early stages of leukocyte recruitment from the blood stream to sites of tissue damage through recognition of the carbohydrate epitope sialyl Lewis-x (sLe-x). Current development of small molecule based inhibitors of this process and their clinical potential to address numerous acute and chronic diseases are explored.
Keywords: selectins, sialyl lewis, adhesion molecules, antagonist, mimetics, inflammation
Mini-Reviews in Medicinal Chemistry
Title: Recent Progress in the Design of Selectin Inhibitors
Volume: 3 Issue: 7
Author(s): Siri Ram Chhabra, Aisyah S. Abdul Rahim and Barrie Kellam
Affiliation:
Keywords: selectins, sialyl lewis, adhesion molecules, antagonist, mimetics, inflammation
Abstract: The selectins are a family of cell-adhesion proteins that mediate the early stages of leukocyte recruitment from the blood stream to sites of tissue damage through recognition of the carbohydrate epitope sialyl Lewis-x (sLe-x). Current development of small molecule based inhibitors of this process and their clinical potential to address numerous acute and chronic diseases are explored.
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Cite this article as:
Chhabra Ram Siri, Rahim S. Abdul Aisyah and Kellam Barrie, Recent Progress in the Design of Selectin Inhibitors, Mini-Reviews in Medicinal Chemistry 2003; 3 (7) . https://dx.doi.org/10.2174/1389557033487791
DOI https://dx.doi.org/10.2174/1389557033487791 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
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