Abstract
A large series of cyclooxygenase-2 (COX-2) inhibitors with diverse skeletons were investigated by means of the Electronic-Topological Method. A system for the COX-2 inhibitor activity prognostication was built with 6 pharmacophores and 6 anti-pharmacophores. The forecasting ability of the system was also tested on different structures, which differ from those that characterize the series studied.
Keywords: cox-2, nsaids, structure-activity relationships (sar)
Mini-Reviews in Medicinal Chemistry
Title: Electronic-Topological Study of Structurally Diverse Cyclooxygenase-2 Inhibitors
Volume: 3 Issue: 4
Author(s): A. Dimoglo, E. Sim, N. Shvets and V. Ahsen
Affiliation:
Keywords: cox-2, nsaids, structure-activity relationships (sar)
Abstract: A large series of cyclooxygenase-2 (COX-2) inhibitors with diverse skeletons were investigated by means of the Electronic-Topological Method. A system for the COX-2 inhibitor activity prognostication was built with 6 pharmacophores and 6 anti-pharmacophores. The forecasting ability of the system was also tested on different structures, which differ from those that characterize the series studied.
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Cite this article as:
Dimoglo A., Sim E., Shvets N. and Ahsen V., Electronic-Topological Study of Structurally Diverse Cyclooxygenase-2 Inhibitors, Mini-Reviews in Medicinal Chemistry 2003; 3 (4) . https://dx.doi.org/10.2174/1389557033488060
DOI https://dx.doi.org/10.2174/1389557033488060 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
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