Abstract
Temporin A, 18 analogs, and a cecropin A-temporin A hybrid peptide were tested with antibiotic sensitive and resistant bacteria, fungi, human erythrocytes, and in clotting assays.Several peptides were active in these assays, and some analogs (D-TA, W1-TA, and Con-L4,G10) may be useful lead compounds for further antibiotics development.The activity of temporin A was found to be dependent upon several of its structural features, including amino acid composition and sequence, chirality, helicity, and positive charge.
Keywords: temporin a, cecropin a, vescp-m, ranatuerin 6, antibiotic peptides, antibiotic resistant bacteria, antifungal, human erythrocyte lysis, hemolysis
Protein & Peptide Letters
Title: Antibiotic Properties of Novel Synthetic Temporin A Analogs and a Cecropin A-Temporin A Hybrid Peptide
Volume: 9 Issue: 6
Author(s): David Wade, Jan-Ingmar Flock, Charlotta Edlund, Ingegerd Lofving-Arvholm, Matti Sallberg, Tomas Bergman, Angela Silveira, Cecille Unson, Louise Rollins-Smith, Jerzy Silberring, Malcom Richardson, Pentti Kuusela and Hilkka Lankinen
Affiliation:
Keywords: temporin a, cecropin a, vescp-m, ranatuerin 6, antibiotic peptides, antibiotic resistant bacteria, antifungal, human erythrocyte lysis, hemolysis
Abstract: Temporin A, 18 analogs, and a cecropin A-temporin A hybrid peptide were tested with antibiotic sensitive and resistant bacteria, fungi, human erythrocytes, and in clotting assays.Several peptides were active in these assays, and some analogs (D-TA, W1-TA, and Con-L4,G10) may be useful lead compounds for further antibiotics development.The activity of temporin A was found to be dependent upon several of its structural features, including amino acid composition and sequence, chirality, helicity, and positive charge.
Export Options
About this article
Cite this article as:
Wade David, Flock Jan-Ingmar, Edlund Charlotta, Lofving-Arvholm Ingegerd, Sallberg Matti, Bergman Tomas, Silveira Angela, Unson Cecille, Rollins-Smith Louise, Silberring Jerzy, Richardson Malcom, Kuusela Pentti and Lankinen Hilkka, Antibiotic Properties of Novel Synthetic Temporin A Analogs and a Cecropin A-Temporin A Hybrid Peptide, Protein & Peptide Letters 2002; 9 (6) . https://dx.doi.org/10.2174/0929866023408409
DOI https://dx.doi.org/10.2174/0929866023408409 |
Print ISSN 0929-8665 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5305 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Focus on Pleiotropic Role of HMGB1 in the Onset of Allergic and Non- Allergic Respiratory Diseases
Current Respiratory Medicine Reviews Synthesis, Anticlotting and Antiplatelet Effects of 1,2,3-Triazoles Derivatives
Medicinal Chemistry QSAR and the Prediction of T-Cell Epitopes
Current Proteomics Substituted Naphthalen-1-yl-Acetic Acid Hydrazides: Synthesis, Antimicrobial Evaluation and QSAR Analysis
Medicinal Chemistry Can Mycobacterial Genomics Generate Novel Targets as Speed-Breakers Against the Race for Drug Resistance
Current Pharmaceutical Design Recent Advances on the Synthesis of Heterocycles from Diazo Compounds
Current Organic Chemistry Extrapulmonary Tuberculosis- Its Management and Control
Current Drug Therapy Recent Developments in Protein and Cell-Targeted Aptamer Selection and Applications
Current Medicinal Chemistry Biochemical Aspects of Nitric Oxide
Current Pharmaceutical Design Chemical and Genetic Engineering Strategies to Improve the Potency of Pharmaceutical Proteins and Enzymes
Current Medicinal Chemistry Cancer Nanotechnology: Emerging Role of Gold Nanoconjugates
Anti-Cancer Agents in Medicinal Chemistry Current Trends in the Application of Nanoparticles in Drug Delivery
Current Medicinal Chemistry Targeting Bacterial RNA Polymerase σ70 for Development of Broadspectrum Antisense Antibacterials
Recent Patents on Anti-Infective Drug Discovery Assessing and Treating Cognitive Impairment in Schizophrenia: Current and Future
Current Pharmaceutical Design New Perspectives of Infections in Cardiovascular Disease
Current Cardiology Reviews Breath Tests in Diagnosis of Pulmonary Tuberculosis
Recent Patents on Biotechnology Benzocaine: Review on a Drug with Unfold Potential
Mini-Reviews in Medicinal Chemistry miR-202 Mediates Metabolic Shift in Lung Cancer Cells via Targeting HK2
Current Signal Transduction Therapy Microwave-mediated Regiospecific Synthesis of Some Novel Annulated Spiro[indoline-3,1`-indolizin]-2-ones
Letters in Organic Chemistry Targeting the Mannose Receptor with Mannosylated Subunit Vaccines
Current Medicinal Chemistry