Abstract
Asymmetric vinylogous aldol reaction is a powerful methodology to introduce a multi functional group in the stereoselective manner. Recently, we have developed highly stereoselective vinylogous Mukaiyama aldol reactions using vinylketene N,O-acetals possessing the chiral oxazolidone. Our methodology has been applied to the asymmetric syntheses of natural products to establish the short and efficient routes. This review focuses on the asymmetric vinylogous Mukaiyama aldol reactions using vinylketene N,O-acetals in total syntheses of natural products.
Keywords: Vinylogous Mukaiyama aldol reaction, vinylketene N, O-acetal, remote stereoinduction, total synthesis, natural product, polyketide
Mini-Reviews in Organic Chemistry
Title: Asymmetric Vinylogous Mukaiyama Aldol Reactions Using Vinylketene N,O-Acetals in Total Syntheses of Natural Products
Volume: 5 Issue: 1
Author(s): Seijiro Hosokawa and Kuniaki Tatsuta
Affiliation:
Keywords: Vinylogous Mukaiyama aldol reaction, vinylketene N, O-acetal, remote stereoinduction, total synthesis, natural product, polyketide
Abstract: Asymmetric vinylogous aldol reaction is a powerful methodology to introduce a multi functional group in the stereoselective manner. Recently, we have developed highly stereoselective vinylogous Mukaiyama aldol reactions using vinylketene N,O-acetals possessing the chiral oxazolidone. Our methodology has been applied to the asymmetric syntheses of natural products to establish the short and efficient routes. This review focuses on the asymmetric vinylogous Mukaiyama aldol reactions using vinylketene N,O-acetals in total syntheses of natural products.
Export Options
About this article
Cite this article as:
Hosokawa Seijiro and Tatsuta Kuniaki, Asymmetric Vinylogous Mukaiyama Aldol Reactions Using Vinylketene N,O-Acetals in Total Syntheses of Natural Products, Mini-Reviews in Organic Chemistry 2008; 5 (1) . https://dx.doi.org/10.2174/157019308783498197
DOI https://dx.doi.org/10.2174/157019308783498197 |
Print ISSN 1570-193X |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6298 |
Call for Papers in Thematic Issues
Applications of Molecular Descriptors in Physicochemical Properties Research of Organic Compounds
Chemical graph theory is concerned with all aspects of the application of graph theory to various areas of chemistry, including organic, theoretical, mathematical, and computational chemistry, as well as in bioinformatics and computational biology. By the use of the term chemical it is emphasized that one is allowed in chemical ...read more
Navigating the 2D Universe in Organic Chemistry
This special issue explores the transformative impact of two-dimensional (2D) materials on the realm of organic chemistry, unraveling new possibilities for synthesis, functionalization, and applications of organic compounds. Focused on the unique chemistry within this novel dimension, the issue highlights breakthroughs in the field of 2D organic chemistry. Contributions are ...read more
Small Molecules, Big Impact: Pioneering Approaches in Anti-inflammatory Care
This thematic issue is dedicated to the latest advancements and research breakthroughs in the realm of anti-inflammatory pharmacotherapy. With inflammation playing a critical role in numerous chronic conditions such as cardiovascular diseases, diabetes, and autoimmune disorders, there is an urgent need for more targeted, effective, and safer anti-inflammatory treatments. This ...read more
Related Journals
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
A Compendium of Volatile Organic Compounds (VOCs) Released By Human Cell Lines
Current Medicinal Chemistry Immunomodulatory Drugs: IMiDs in Acute Myeloid Leukemia (AML)
Current Drug Targets The Roles of Programmed Cell Death Ligand-1/ Programmed Cell Death-1 (PD-L1/PD-1) in HPV-induced Cervical Cancer and Potential for their Use in Blockade Therapy
Current Medicinal Chemistry Antisense Targets to Enhance Hormone and Cytotoxic Therapies in Advanced Prostate Cancer
Current Drug Targets Targeting the Cancer-Stroma Interaction: A Potential Approach for Pancreatic Cancer Treatment
Current Pharmaceutical Design Prediction and Monitoring of Therapeutic Response by Molecular Imaging
Current Medical Imaging Sublethal Total Body Irradiation Leads to Early Cerebellar Damage and Oxidative Stress
Current Neurovascular Research Targeting Cancer with Epi-Drugs: A Precision Medicine Perspective
Current Pharmaceutical Biotechnology Advanced Assessment of the Endogenous Hormone Level as a Potential Biomarker of the Urogenital Tract Cancer
Combinatorial Chemistry & High Throughput Screening Interactome Analysis of the Differentially Expressed Proteins in Uterine Leiomyoma
Anti-Cancer Agents in Medicinal Chemistry Synthesis of Silica Based Nanoparticles Against the Proliferation of Human Prostate Cancer
Anti-Cancer Agents in Medicinal Chemistry Recent Progress in the Identification and Clinical Evaluation of Inhibitors of the Mitotic Kinesin KSP
Current Topics in Medicinal Chemistry Recent Research Trends on Bismuth Compounds in Cancer Chemoand Radiotherapy
Current Medicinal Chemistry Ferritin and Percent Transferrin Saturation Levels Predict Type 2 Diabetes Risk and Cardiovascular Disease Outcomes
Current Diabetes Reviews SANTAVAC ™: A Novel Universal Antigen Composition for Developing Cancer Vaccines
Recent Patents on Biotechnology Drug-Drug Interactions: Antiretroviral Drugs and Recreational Drugs
Recent Patents on CNS Drug Discovery (Discontinued) Peptides in Oral Diseases
Current Pharmaceutical Design Controlled Somatic and Germline Copy Number Variation in the Mouse Model
Current Genomics New Alkyl-Lipid Blockers of SK3 Channels Reduce Cancer Cell Migration and Occurrence of Metastasis
Current Cancer Drug Targets Chemometric Evaluation of the Significance of Molecular Structural Descriptors on Binding of Acridinone Derivatives to DNA
Letters in Drug Design & Discovery