Abstract
Neonatal diabetes mellitus (NDM) is a rare cause of hyperglycemia in the neonatal period. We encountered a patient with neonatal diabetes mellitus and exocrine pancreatic insufficiency secondary to a homozygous insulin promoter factor-1 (IPF1) mutation. We sought to review the available literature regarding current etiologies and therapeutic options available to patients with NDM. Identification of genetic mutations and further investigation of neonatal diabetes mellitus has allowed for improvement in patient care and a better understanding of the etiology of neonatal diabetes mellitus. Given the rarity of the condition, the neonatologist, pediatrician and family practitioner must be aware of these changes in order to organize and facilitate appropriate care.
Keywords: Neonatal diabetes mellitus, IPF-1, pancreatic agenesis, hyperglycemia
Current Pediatric Reviews
Title: Neonatal Diabetes: Applying Molecular Biology to Patient Care
Volume: 4 Issue: 2
Author(s): Rebecca Vartanian and Steven M. Donn
Affiliation:
Keywords: Neonatal diabetes mellitus, IPF-1, pancreatic agenesis, hyperglycemia
Abstract: Neonatal diabetes mellitus (NDM) is a rare cause of hyperglycemia in the neonatal period. We encountered a patient with neonatal diabetes mellitus and exocrine pancreatic insufficiency secondary to a homozygous insulin promoter factor-1 (IPF1) mutation. We sought to review the available literature regarding current etiologies and therapeutic options available to patients with NDM. Identification of genetic mutations and further investigation of neonatal diabetes mellitus has allowed for improvement in patient care and a better understanding of the etiology of neonatal diabetes mellitus. Given the rarity of the condition, the neonatologist, pediatrician and family practitioner must be aware of these changes in order to organize and facilitate appropriate care.
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Cite this article as:
Vartanian Rebecca and Donn M. Steven, Neonatal Diabetes: Applying Molecular Biology to Patient Care, Current Pediatric Reviews 2008; 4 (2) . https://dx.doi.org/10.2174/157339608784462016
DOI https://dx.doi.org/10.2174/157339608784462016 |
Print ISSN 1573-3963 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6336 |
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