Abstract
Small molecules targeting p53 represent an emerging group of potentially useful agents for the improvement of antitumor therapy. These modulators include agents that activate wild-type p53 or reactivate mutant p53 and inhibitors of p53 functions. Preclinical evidences support the interest of combination strategies with conventional antitumor agents.
Keywords: p53, nutlins, pifithrins, histone deacetylase inhibitors, ubiquitin ligase inhibitors, apoptosis, cancer cells, drug combination
Mini-Reviews in Medicinal Chemistry
Title: Small Molecules Targeting p53 to Improve Antitumor Therapy
Volume: 8 Issue: 9
Author(s): G. L. Beretta, L. Gatti, V. Benedetti, P. Perego and F. Zunino
Affiliation:
Keywords: p53, nutlins, pifithrins, histone deacetylase inhibitors, ubiquitin ligase inhibitors, apoptosis, cancer cells, drug combination
Abstract: Small molecules targeting p53 represent an emerging group of potentially useful agents for the improvement of antitumor therapy. These modulators include agents that activate wild-type p53 or reactivate mutant p53 and inhibitors of p53 functions. Preclinical evidences support the interest of combination strategies with conventional antitumor agents.
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Cite this article as:
Beretta L. G., Gatti L., Benedetti V., Perego P. and Zunino F., Small Molecules Targeting p53 to Improve Antitumor Therapy, Mini-Reviews in Medicinal Chemistry 2008; 8 (9) . https://dx.doi.org/10.2174/138955708785132774
DOI https://dx.doi.org/10.2174/138955708785132774 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
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