Abstract
An efficient synthesis of the selective H4 receptor agonist 4-methylhistamine is described. This approach can be used to prepare, without purification steps and in high yield, significant quantities of the product, useful as pharmacological tool to investigate the physiological roles of the histamine H4 receptor.
Keywords: 4-methylhistamine, histamine, H4-receptor, n-butyllithium, H4-agonist, yield
Letters in Organic Chemistry
Title: A Short and Efficient Synthesis of the Selective H4 Receptor Agonist 4- Methylhistamine
Volume: 6 Issue: 1
Author(s): Mirko Rivara, Valentina Zuliani, Pier V. Plazzi and Fabrizio Bordi
Affiliation:
Keywords: 4-methylhistamine, histamine, H4-receptor, n-butyllithium, H4-agonist, yield
Abstract: An efficient synthesis of the selective H4 receptor agonist 4-methylhistamine is described. This approach can be used to prepare, without purification steps and in high yield, significant quantities of the product, useful as pharmacological tool to investigate the physiological roles of the histamine H4 receptor.
Export Options
About this article
Cite this article as:
Rivara Mirko, Zuliani Valentina, Plazzi V. Pier and Bordi Fabrizio, A Short and Efficient Synthesis of the Selective H4 Receptor Agonist 4- Methylhistamine, Letters in Organic Chemistry 2009; 6 (1) . https://dx.doi.org/10.2174/157017809787003223
DOI https://dx.doi.org/10.2174/157017809787003223 |
Print ISSN 1570-1786 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6255 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Reviving an Old HIV-1 Gene: The HIV-1 Antisense Protein
Current HIV Research Supplementation, Optimal Status, and Analytical Determination of Vitamin D: Where are we Standing in 2012?
Anti-Cancer Agents in Medicinal Chemistry Preface [Hot topic: Insulin Resistance and Impaired Coronary Endothelial Function (Guest Editor: Teruo Inoue)]
Current Drug Targets - Cardiovascular & Hematological Disorders The Quinolone Family: From Antibacterial to Anticancer Agents
Current Medicinal Chemistry - Anti-Cancer Agents Influence of Adrenalectomy on Protective Effects of Urocortin I, a Corticotropin-Releasing Factor, Against Indomethacin-Induced Enteropathy in Rats
Current Neuropharmacology Rational Design and Development of RDP58
Current Pharmaceutical Design Quantum-Mechanical Studies of Reactions Performed by Cytochrome P450 Enzymes
Current Inorganic Chemistry (Discontinued) Application of HPLC to Investigate the Physicochemical Properties and Intestinal Permeability of Ketoprofen
Current Pharmaceutical Analysis Xanthoangelol Isolated from Angelica keiskei Roots Prevents Dextran Sulfate Sodium-Treated Colitis in Mice
The Natural Products Journal Bioactive Hydrogel Scaffolds - Advances in Cartilage Regeneration Through Controlled Drug Delivery
Current Pharmaceutical Design Generation of Regulatory T Cells to Antigen Expressed in the Retina
Current Immunology Reviews (Discontinued) The DOCA-Salt Hypertensive Rat as a Model of Cardiovascular Oxidative and Inflammatory Stress
Current Cardiology Reviews Vitamin D Intervention Trials in Critical Illness
Inflammation & Allergy - Drug Targets (Discontinued) Neurovirulence of SARS CoV2: From Clinical Data to Preclinical Neuropsychological Exploration
Coronaviruses Type 2 Diabetes As An Inflammatory Cardiovascular Disorder
Current Molecular Medicine Novel, Acidic CCR2 Receptor Antagonists: From Hit to Lead
Letters in Drug Design & Discovery Targets of Anti-glucocorticoid Therapy for Stress-related Diseases
Recent Patents on CNS Drug Discovery (Discontinued) Design, Synthesis, and Structure-Activity Relationship Study of Peroxisome Proliferator-Activated Receptor (PPAR) δ-Selective Ligands
Current Medicinal Chemistry The Role of Fibroblast Growth Factor 21 (FGF21) on Energy Balance, Glucose and Lipid Metabolism
Current Diabetes Reviews Ledipasvir/Sofosbuvir versus Daclatasvir/Sofosbuvir for the Treatment of Chronic Hepatitis C Genotype 4 Patients
Current Drug Safety