Abstract
Mitogen-activated protein kinases (MAPKs) are key components of cellular signal transduction. It is the objective of this communication to demonstrate that insight into protein-protein interactions in the Common Docking motif of yeast mitogen-activated protein kinases can be obtained based on homology models. Homology models for four yeast MAPKs, FUS3, KSS1, HOG1 and MPK1 were built based on the X-ray structures of active and inactive rat ERK2. The structural motifs required for the basis of specificity were rationalized based on these structures.
Keywords: Homology, molecular modeling, common docking motif, yeast, mitogen-activated protein kinase, signal transduction
Protein & Peptide Letters
Title: Homology Modeling Studies of Yeast Mitogen-Activated Protein Kinases (MAPKS): Structural Motifs as a Basis for Specificity
Volume: 17 Issue: 6
Author(s): D.L. Smith and S.H. Nilar
Affiliation:
Keywords: Homology, molecular modeling, common docking motif, yeast, mitogen-activated protein kinase, signal transduction
Abstract: Mitogen-activated protein kinases (MAPKs) are key components of cellular signal transduction. It is the objective of this communication to demonstrate that insight into protein-protein interactions in the Common Docking motif of yeast mitogen-activated protein kinases can be obtained based on homology models. Homology models for four yeast MAPKs, FUS3, KSS1, HOG1 and MPK1 were built based on the X-ray structures of active and inactive rat ERK2. The structural motifs required for the basis of specificity were rationalized based on these structures.
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Smith D.L. and Nilar S.H., Homology Modeling Studies of Yeast Mitogen-Activated Protein Kinases (MAPKS): Structural Motifs as a Basis for Specificity, Protein & Peptide Letters 2010; 17 (6) . https://dx.doi.org/10.2174/092986610791190327
DOI https://dx.doi.org/10.2174/092986610791190327 |
Print ISSN 0929-8665 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5305 |
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