Abstract
Many retinal dystrophies are associated with photoreceptor loss, which causes irreversible blindness. The recent identification of various sources of stem cells in the mammalian retina has raised the possibility that cell-based therapies might be efficient strategies to treat a wide range of incurable eye diseases. A first step towards the successful therapeutic exploitation of these cells is to unravel intrinsic and extrinsic regulators that control their proliferation and cell lineage determination. In this review, we provide an overview of the different types and molecular fingerprints of retinal stem cells identified so far. We also detail the current knowledge on molecular cues that influence their self-renewal and proliferation capacity. In particular, we focus on recent data implicating developmental signaling pathways, such as Wnt, Notch and Hedeghog, both in the normal and regenerating retina in different animal models. Last, we discuss the potential of ES cells and various adult stem cells for retinal repair.
Keywords: Retina, neural stem cells, regeneration, Muller glial cells, retinal pigment epithelium, canonical Wnt signaling, Hedgehog signaling, Notch/Delta pathway
Current Stem Cell Research & Therapy
Title: Stemness or Not Stemness? Current Status and Perspectives of Adult Retinal Stem Cells
Volume: 4 Issue: 2
Author(s): Morgane Locker, Caroline Borday and Muriel Perron
Affiliation:
Keywords: Retina, neural stem cells, regeneration, Muller glial cells, retinal pigment epithelium, canonical Wnt signaling, Hedgehog signaling, Notch/Delta pathway
Abstract: Many retinal dystrophies are associated with photoreceptor loss, which causes irreversible blindness. The recent identification of various sources of stem cells in the mammalian retina has raised the possibility that cell-based therapies might be efficient strategies to treat a wide range of incurable eye diseases. A first step towards the successful therapeutic exploitation of these cells is to unravel intrinsic and extrinsic regulators that control their proliferation and cell lineage determination. In this review, we provide an overview of the different types and molecular fingerprints of retinal stem cells identified so far. We also detail the current knowledge on molecular cues that influence their self-renewal and proliferation capacity. In particular, we focus on recent data implicating developmental signaling pathways, such as Wnt, Notch and Hedeghog, both in the normal and regenerating retina in different animal models. Last, we discuss the potential of ES cells and various adult stem cells for retinal repair.
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Cite this article as:
Locker Morgane, Borday Caroline and Perron Muriel, Stemness or Not Stemness? Current Status and Perspectives of Adult Retinal Stem Cells, Current Stem Cell Research & Therapy 2009; 4 (2) . https://dx.doi.org/10.2174/157488809788167382
DOI https://dx.doi.org/10.2174/157488809788167382 |
Print ISSN 1574-888X |
Publisher Name Bentham Science Publisher |
Online ISSN 2212-3946 |
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