Abstract
We report a case with severe persistent pulmonary hypertension (PPHN) associated with congenital cystic adenomatoid malformation of the lung (CCAM) treated with sildenafil PO. The case was unresponsive to the High-Frequency Oscillatory Ventilation (HFOV), with a oxygenation index (OI) of 50 before sildenafil. Substantial improvement in OI was followed by extubation and survival. No side-effects were noted.
Keywords: PPHN, CCAM, sildenafil, HFOV, oxygenation index
Current Pediatric Reviews
Title: Neonatal Persistent Pulmonary Hypertension Associated with Congenital Cystic Adenomatoid Malformation Treated with Sildenafil: Case Report
Volume: 5 Issue: 2
Author(s): Gianfranco Maffei, Vincenzo Manuppelli and Rosario Magaldi
Affiliation:
Keywords: PPHN, CCAM, sildenafil, HFOV, oxygenation index
Abstract: We report a case with severe persistent pulmonary hypertension (PPHN) associated with congenital cystic adenomatoid malformation of the lung (CCAM) treated with sildenafil PO. The case was unresponsive to the High-Frequency Oscillatory Ventilation (HFOV), with a oxygenation index (OI) of 50 before sildenafil. Substantial improvement in OI was followed by extubation and survival. No side-effects were noted.
Export Options
About this article
Cite this article as:
Maffei Gianfranco, Manuppelli Vincenzo and Magaldi Rosario, Neonatal Persistent Pulmonary Hypertension Associated with Congenital Cystic Adenomatoid Malformation Treated with Sildenafil: Case Report, Current Pediatric Reviews 2009; 5 (2) . https://dx.doi.org/10.2174/157339609788185767
DOI https://dx.doi.org/10.2174/157339609788185767 |
Print ISSN 1573-3963 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6336 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Defining the Molecular Nexus of Cancer, Type 2 Diabetes and Cardiovascular Disease
Current Molecular Medicine Beta-Blockers are Associated with Decreased In-Hospital Mortality and Stroke in Acute Decompensated Heart Failure: Findings from a Retrospective Analysis of a 22-Year Registry in the Middle East (1991-2013)
Current Vascular Pharmacology No Effect of Metformin on Ovarian Cancer Survival: A Systematic Review and Meta-Analysis of Cohort Studies
Current Pharmaceutical Design Sodium Intake Recommendations: A Subject that Needs to be Reconsidered
Current Hypertension Reviews Vascular Endothelial Growth Factor as an Anti-Angiogenic Target for Cancer Therapy
Current Drug Targets Chaos and Gene expression: A Theoretical Approach
Recent Patents on Biomedical Engineering (Discontinued) Is There a Role for Oral Anticoagulant Therapy in Patients with Peripheral Arterial Disease?
Current Drug Targets - Cardiovascular & Hematological Disorders On the Structural Basis of the Hypertensive Properties of Angiotensin II: A Solved Mystery or a Controversial Issue?
Current Topics in Medicinal Chemistry Molecular Hydrogen: New Antioxidant and Anti-inflammatory Therapy for Rheumatoid Arthritis and Related Diseases
Current Pharmaceutical Design Site-related Effects of Relaxin in the Gastrointestinal Tract Through Nitric Oxide Signalling: An Updated Report
Current Protein & Peptide Science Severe Hyponatremia and Other Electrolyte Disturbances Associated with Indapamide
Current Drug Safety Sympathetic Nervous System, Genes and Human Essential Hypertension
Current Neurovascular Research Stem Cells and Cardiovascular Repair: A Role for Natural and Synthetic Molecules Harboring Differentiating and Paracrine Logics
Cardiovascular & Hematological Agents in Medicinal Chemistry PDE5 Inhibitors and their Applications
Current Medicinal Chemistry Treatments for Obesity-Related Hypertension
Current Hypertension Reviews Type 1 Diabetes Mellitus - Risk Factor for Cardiovascular Disease Morbidity and Mortality
Current Diabetes Reviews Is there a Teratogenicity Risk Associated with Cannabis and Synthetic Cannabimimetics’ (‘Spice’) Intake?
CNS & Neurological Disorders - Drug Targets Classical and New Renin-Angiotensin Signalling in Atherosclerosis
Current Signal Transduction Therapy The Emerging Role of Arginase in Endothelial Dysfunction in Diabetes
Current Vascular Pharmacology Biological Activities of Receptor-interacting Protein 140 in Adipocytes and Metabolic Diseases
Current Diabetes Reviews