Abstract
IMiDs compounds are a class of analogues of thalidomide, with greater immunomodulatory activity and a superior safety profile compared to the parent compound. They show substantial increase in potency and an interesting tolerability profile, primarily due to a decreased incidence of the most severe side effect of thalidomide, i.e. Chemotherapy- Induced Peripheral Neurotoxicity (CIPN). These novel aspects of the IMiDs compounds will be discussed.
Keywords: IMiDs, thalidomide, CC-5013, lenalidomide, CC-4047, pomalidomide, safety, side effects, CIPN
Mini-Reviews in Medicinal Chemistry
Title: Thalidomide Chemotherapy-Induced Peripheral Neuropathy: Actual Status and New Perspectives with Thalidomide Analogues Derivatives
Volume: 9 Issue: 7
Author(s): Sante Cundari and Guido Cavaletti
Affiliation:
Keywords: IMiDs, thalidomide, CC-5013, lenalidomide, CC-4047, pomalidomide, safety, side effects, CIPN
Abstract: IMiDs compounds are a class of analogues of thalidomide, with greater immunomodulatory activity and a superior safety profile compared to the parent compound. They show substantial increase in potency and an interesting tolerability profile, primarily due to a decreased incidence of the most severe side effect of thalidomide, i.e. Chemotherapy- Induced Peripheral Neurotoxicity (CIPN). These novel aspects of the IMiDs compounds will be discussed.
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Cundari Sante and Cavaletti Guido, Thalidomide Chemotherapy-Induced Peripheral Neuropathy: Actual Status and New Perspectives with Thalidomide Analogues Derivatives, Mini-Reviews in Medicinal Chemistry 2009; 9 (7) . https://dx.doi.org/10.2174/138955709788452595
DOI https://dx.doi.org/10.2174/138955709788452595 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
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