Abstract
Iron is essential for human life, however it can be toxic through Fe ability to generate oxygen-derived radicals. This work reviews the main features of Fe binding in the cell and its association to these processes. The chemical nature of the Fe extracted by chelation therapy in pathophysiological situations is also analyzed.
Mini-Reviews in Medicinal Chemistry
Title: Forms of Iron Binding in the Cells and the Chemical Features of Chelation Therapy
Volume: 9 Issue: 9
Author(s): S. Puntarulo and M. Galleano
Affiliation:
Abstract: Iron is essential for human life, however it can be toxic through Fe ability to generate oxygen-derived radicals. This work reviews the main features of Fe binding in the cell and its association to these processes. The chemical nature of the Fe extracted by chelation therapy in pathophysiological situations is also analyzed.
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Cite this article as:
Puntarulo S. and Galleano M., Forms of Iron Binding in the Cells and the Chemical Features of Chelation Therapy, Mini-Reviews in Medicinal Chemistry 2009; 9 (9) . https://dx.doi.org/10.2174/138955709788922674
DOI https://dx.doi.org/10.2174/138955709788922674 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
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