Abstract
The prevalences of overweightedness and obesity are increasing globally at frightening rates, driven by social and economic changes. Furthermore, obesity is associated with the pathogeneses of major diseases, particularly diabetes and cardiovascular diseases. However, no satisfactorily safe, effective obesity drugs are commercially available at the present time. Only two drugs have been approved in the United States for the long-term treatment of obesity, sibutramine and orlistat. However, these drugs are minimally effective and have significant side effects, which are likely inhibit their use. Therefore, there is a huge opportunity to make a significant impact on the lives of obese people through the discovery and development of additional pharmacotherapeutic options. In this review article, the authors focus on selected trends in medicinal chemistry and the approaches used to develop drugs for treating obesity.
Keywords: Antiobesity, CB1, MC4R, MCH1R, neuropeptide Y family, aminergic receptor modulator
Current Topics in Medicinal Chemistry
Title: New Trends in Medicinal Chemistry Approaches to Antiobesity Therapy
Volume: 9 Issue: 6
Author(s): Jinhwa Lee, Kwang-Seop Song, Jahyo Kang, Suk Ho Lee and Junwon Lee
Affiliation:
Keywords: Antiobesity, CB1, MC4R, MCH1R, neuropeptide Y family, aminergic receptor modulator
Abstract: The prevalences of overweightedness and obesity are increasing globally at frightening rates, driven by social and economic changes. Furthermore, obesity is associated with the pathogeneses of major diseases, particularly diabetes and cardiovascular diseases. However, no satisfactorily safe, effective obesity drugs are commercially available at the present time. Only two drugs have been approved in the United States for the long-term treatment of obesity, sibutramine and orlistat. However, these drugs are minimally effective and have significant side effects, which are likely inhibit their use. Therefore, there is a huge opportunity to make a significant impact on the lives of obese people through the discovery and development of additional pharmacotherapeutic options. In this review article, the authors focus on selected trends in medicinal chemistry and the approaches used to develop drugs for treating obesity.
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Cite this article as:
Lee Jinhwa, Song Kwang-Seop, Kang Jahyo, Lee Ho Suk and Lee Junwon, New Trends in Medicinal Chemistry Approaches to Antiobesity Therapy, Current Topics in Medicinal Chemistry 2009; 9 (6) . https://dx.doi.org/10.2174/156802609788897853
DOI https://dx.doi.org/10.2174/156802609788897853 |
Print ISSN 1568-0266 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4294 |
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