Abstract
Benchmarking B-cell epitope prediction for vaccine design is meaningful if based on empirical reference data pertaining to cross-reactivities of antipeptide antibodies with native protein antigens; yet it is complicated by such data acquired using antibodies raised against peptide-protein conjugates, as peptide-protein conjugation can differentially suppress antibody responses to peptide epitopes.
Keywords: B-cell epitope prediction, peptide-based vaccine, antipeptide antibody, peptide-protein cross-reactivity, peptideprotein conjugation, structural energetics
Protein & Peptide Letters
Title: Immunization with Peptide-Protein Conjugates: Impact on Benchmarking B-Cell Epitope Prediction for Vaccine Design
Volume: 17 Issue: 3
Author(s): Salvador Eugenio C. Caoili
Affiliation:
Keywords: B-cell epitope prediction, peptide-based vaccine, antipeptide antibody, peptide-protein cross-reactivity, peptideprotein conjugation, structural energetics
Abstract: Benchmarking B-cell epitope prediction for vaccine design is meaningful if based on empirical reference data pertaining to cross-reactivities of antipeptide antibodies with native protein antigens; yet it is complicated by such data acquired using antibodies raised against peptide-protein conjugates, as peptide-protein conjugation can differentially suppress antibody responses to peptide epitopes.
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Cite this article as:
Caoili C. Salvador Eugenio, Immunization with Peptide-Protein Conjugates: Impact on Benchmarking B-Cell Epitope Prediction for Vaccine Design, Protein & Peptide Letters 2010; 17 (3) . https://dx.doi.org/10.2174/092986610790780288
DOI https://dx.doi.org/10.2174/092986610790780288 |
Print ISSN 0929-8665 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5305 |
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