Abstract
The aim of this review is to provide the reader with an overview on the potential of dendritic polymers in the antisense delivery technology. Special emphasis has been placed on the different types of dendritic structures that have been reported and the modifications performed to increase their efficacy and safety. Therefore the advances made in their chemistry and how it has been adapted to meet the specific requirements of the antisense delivery technology are reviewed and discussed.
Keywords: Dendrimers, dendriplexes, gene silencing, antisense therapy, antisense delivery, siRNA delivery, gene therapy, knocking down
Mini-Reviews in Medicinal Chemistry
Title: Knocking Down Gene Expression with Dendritic Vectors
Volume: 10 Issue: 1
Author(s): M. Ravina, P. Paolicelli, B. Seijo and A. Sanchez
Affiliation:
Keywords: Dendrimers, dendriplexes, gene silencing, antisense therapy, antisense delivery, siRNA delivery, gene therapy, knocking down
Abstract: The aim of this review is to provide the reader with an overview on the potential of dendritic polymers in the antisense delivery technology. Special emphasis has been placed on the different types of dendritic structures that have been reported and the modifications performed to increase their efficacy and safety. Therefore the advances made in their chemistry and how it has been adapted to meet the specific requirements of the antisense delivery technology are reviewed and discussed.
Export Options
About this article
Cite this article as:
Ravina M., Paolicelli P., Seijo B. and Sanchez A., Knocking Down Gene Expression with Dendritic Vectors, Mini-Reviews in Medicinal Chemistry 2010; 10 (1) . https://dx.doi.org/10.2174/138955710791112569
DOI https://dx.doi.org/10.2174/138955710791112569 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
Call for Papers in Thematic Issues
Bioprospecting of Natural Products as Sources of New Multitarget Therapies
According to the Convention on Biological Diversity, bioprospecting is the exploration of biodiversity and indigenous knowledge to develop commercially valuable products for pharmaceutical and other applications. Bioprospecting involves searching for useful organic compounds in plants, fungi, marine organisms, and microorganisms. Natural products traditionally constituted the primary source of more than ...read more
Computational Frontiers in Medicinal Chemistry
The thematic issue "Computational Frontiers in Medicinal Chemistry" provides a robust platform for delving into state-of-the-art computational methodologies and technologies that significantly propel advancements in medicinal chemistry. This edition seeks to amalgamate top-tier reviews spotlighting the latest trends and breakthroughs in the fusion of computational approaches, including artificial intelligence (AI) ...read more
Mitochondria as a Therapeutic Target in Metabolic Disorders
Mitochondria are the primary site of adenosine triphosphate (ATP) production in mammalian cells. Moreover, these organelles are an important source of reactive oxygen and nitrogen species in virtually any nucleated cell type. The modulation of a myriad of cellular signaling pathways depends on the mitochondrial physiology. Mitochondrial dysfunction is observed ...read more
Natural Products and Dietary Supplements in Alleviation of Metabolic, Cardiovascular, and Neurological Disorders
Metabolic disorders like diabetes, obesity, inflammation, oxidative stress, cancer etc, cardiovascular disorders like angina, myocardial infarction, congestive heart failure etc as well as neurological disorders like Alzheimer?s, Parkinson?s, Epilepsy, Depression, etc are the global burden. They covered the major segment of the diseases and disorders from which the human community ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Anti-Cancer Drug Discovery: Structure, Function and Novel Strategy – Part-4
Current Topics in Medicinal Chemistry Signal Transduction Pathways and Transcriptional Mechanisms as Targets for Prevention of Emergence of Multidrug Resistance in Human Cancer Cells
Current Drug Targets In Silico Design of Protein Kinase Inhibitors: Successes and Failures
Anti-Cancer Agents in Medicinal Chemistry Vitamin D Analogs in Cutaneous Malignancies
Current Pharmaceutical Design Green Chemistry Approach as a Versatile Platform for Nanoparticles with Biomedical Applications
Nanoscience & Nanotechnology-Asia Breast Cancer: Current Developments in Molecular Approaches to Diagnosis and Treatment
Recent Patents on Anti-Cancer Drug Discovery Approaches Targeting KV10.1 Open a Novel Window for Cancer Diagnosis and Therapy
Current Medicinal Chemistry Chemical & RNAi Screening at MSKCC: A Collaborative Platform to Discover & Repurpose Drugs to Fight Disease
Combinatorial Chemistry & High Throughput Screening A Short Overview on the Biomedical Applications of Silica, Alumina and Calcium Phosphate-based Nanostructured Materials
Current Medicinal Chemistry VFP: A Visual Algorithm for Predicting Gene Fusion in RNA-Seq Data
Current Bioinformatics Anticancer Immunotherapy in Combination with Proapoptotic Therapy
Current Cancer Drug Targets Modulation of MicroRNAs by <i>Euphorbia Microsciadia</i> Boiss in MDA-MB-231 Cell Line: New Possibilities in Breast Cancer Therapy
Recent Patents on Anti-Cancer Drug Discovery Dietary Phytochemicals in Chemoprevention of Cancer
Current Medicinal Chemistry - Immunology, Endocrine & Metabolic Agents CARD Proteins as Therapeutic Targets in Cancer
Current Drug Targets Immune System Induction of Nerve Growth Factor in an Animal Model of Multiple Sclerosis: Implications in Re-Myelination and Myelin RepairATION AND MYELIN REPAIR
CNS & Neurological Disorders - Drug Targets Interaction of Natural and Synthetic Anthracyclines with DNA (Supporting Material)
Current Bioactive Compounds Application of Pharmacogenomics to Dietary Cancer Chemoprevention
Current Pharmacogenomics Cellular Changes, Molecular Pathways and the Immune System Following Photodynamic Treatment
Current Medicinal Chemistry A Comparison of the Biological Properties of Small Molecular Weight Agonists and Antagonists of CD200:CD200R Interactions
Medicinal Chemistry Reposition of the Fungicide Ciclopirox for Cancer Treatment
Recent Patents on Anti-Cancer Drug Discovery