Abstract
Proteins of Bcl-2(B-cell lymphoma-2) family are key regulators of programmed cell death. Scientist found that some members of this family are over-expressed in malignant tumors and influence the sensitivity of tumor cells to chemotherapy and radiotherapy. This report reviews the recent progress of structures, functions and inhibition of Bcl-2 family proteins, especially the development of Bcl-2 inhibitors in past decades as anticancer agents.
Keywords: Apoptosis, Bcl-2, structure, function, inhibitors, anti-tumor
Mini-Reviews in Medicinal Chemistry
Title: Structure, Function and Inhibition of Bcl-2 Family Proteins: A New Target for Anti-Tumor Agents
Volume: 9 Issue: 14
Author(s): Guizhi Xiao, Hao Fang, Chengguo Xing and Wenfang Xu
Affiliation:
Keywords: Apoptosis, Bcl-2, structure, function, inhibitors, anti-tumor
Abstract: Proteins of Bcl-2(B-cell lymphoma-2) family are key regulators of programmed cell death. Scientist found that some members of this family are over-expressed in malignant tumors and influence the sensitivity of tumor cells to chemotherapy and radiotherapy. This report reviews the recent progress of structures, functions and inhibition of Bcl-2 family proteins, especially the development of Bcl-2 inhibitors in past decades as anticancer agents.
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Cite this article as:
Xiao Guizhi, Fang Hao, Xing Chengguo and Xu Wenfang, Structure, Function and Inhibition of Bcl-2 Family Proteins: A New Target for Anti-Tumor Agents, Mini-Reviews in Medicinal Chemistry 2009; 9 (14) . https://dx.doi.org/10.2174/138955709791012238
DOI https://dx.doi.org/10.2174/138955709791012238 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
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