Abstract
Enantioselective hydrolysis of methyl ester of (±)-C75 was successfully accomplished by means of Acylase I from Aspergillus to afford (2R,3S)-(+)-C75 with 96% e.e. The unreacted methyl ester was recovered with > 99% e.e. This latter compound was either chemically or enzymatically hydrolyzed to furnish (2S,3R)-( – )-C75 with > 99% e.e.
Keywords: C75, enzymatic resolution, α-methylene-γ-butyrolactone, paraconic acid, Acylase I
Letters in Organic Chemistry
Title: The First Kinetic Enzymatic Resolution of Methyl Ester of C75
Volume: 7 Issue: 3
Author(s): Kuheli Chakrabarty, Cristina Forzato, Patrizia Nitti, Giuliana Pitacco and Ennio Valentin
Affiliation:
Keywords: C75, enzymatic resolution, α-methylene-γ-butyrolactone, paraconic acid, Acylase I
Abstract: Enantioselective hydrolysis of methyl ester of (±)-C75 was successfully accomplished by means of Acylase I from Aspergillus to afford (2R,3S)-(+)-C75 with 96% e.e. The unreacted methyl ester was recovered with > 99% e.e. This latter compound was either chemically or enzymatically hydrolyzed to furnish (2S,3R)-( – )-C75 with > 99% e.e.
Export Options
About this article
Cite this article as:
Chakrabarty Kuheli, Forzato Cristina, Nitti Patrizia, Pitacco Giuliana and Valentin Ennio, The First Kinetic Enzymatic Resolution of Methyl Ester of C75, Letters in Organic Chemistry 2010; 7 (3) . https://dx.doi.org/10.2174/157017810791112405
DOI https://dx.doi.org/10.2174/157017810791112405 |
Print ISSN 1570-1786 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6255 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Combined Chemotherapy or Biotherapy with Jasmonates: Targeting Energy Metabolism for Cancer Treatment
Current Pharmaceutical Biotechnology 3-(Adamantan-1-yl)-4-hydroxybenzyl Substituted Purines and Pyrimidines: Synthesis and Cytotoxic Activity
Letters in Drug Design & Discovery Targeting Glioblastoma: The Current State of Different Therapeutic Approaches
Current Neuropharmacology Editorial
Anti-Cancer Agents in Medicinal Chemistry The Role of MRI in Treatment Planning for Rectal Cancer - A Review
Current Cancer Therapy Reviews Endogenous Angiogenesis Inhibitors as Therapeutic Agents: Historical Perspective and Future Direction
Recent Patents on Anti-Cancer Drug Discovery p53: An Attractive Therapeutic Target for Cancer
Current Medicinal Chemistry A Unique Intracellular, Extracellular and Transmembrane Circulation of Potassium Ions in the Auditory Inner Ear as an Anticarcinogenic Principle? Part 1
Inflammation & Allergy - Drug Targets (Discontinued) Analysis of Anticancer Drugs and their Metabolites by Mass Spectrometry
Current Drug Metabolism Stemness Phenotype in Tamoxifen Resistant Breast Cancer Cells May be Induced by Interactions Between Receptor Tyrosine Kinases and ERα-66
Recent Patents on Anti-Cancer Drug Discovery Meet Our Editorial Board Member
Recent Patents on Anti-Cancer Drug Discovery Current Management of Neonatal Liver Tumors
Current Pediatric Reviews Combination Treatment of Glioblastoma by Low-Dose Radiation and Genistein
Current Radiopharmaceuticals Drug Delivery Systems with Modified Release for Systemic and Biophase Bioavailability
Current Clinical Pharmacology Telomerase Inhibitors as Anticancer Therapy
Current Medicinal Chemistry - Anti-Cancer Agents Plant Cells as Pharmaceutical Factories
Current Pharmaceutical Design Nanoparticle-based Cerebral Drug-Delivery Systems and Antiangiogenic Approach in Gliomas Treatment
Recent Patents on Nanotechnology Histone Deacetylase Inhibitors: An Attractive Strategy for Cancer Therapy
Current Medicinal Chemistry Erratum
Current Proteomics Recent Advances in Optical Mammography
Current Medical Imaging