Abstract
Aging is an inherently complex process and the manifestations occur within an organism at genetic, molecular, cellular, organ, and system levels. It is now believed that aging results from a complex interplay between multiple mechanisms including oxidative stress, mitochondrial DNA damage, membrane alterations, telomere loss, apoptosis and genetic mechanisms. All the above mentioned processes contribute towards the process of aging and may underlie the age related changes. The current understanding of aging process has given novel insights in potential anti-aging interventions. The current strategies for anti-aging interventions include anti-oxidant supplementation, hormonal treatment, caloric restriction, and genetic and cellular engineering techniques. Any given intervention to be acknowledged as anti-aging must be able to demonstrate delayed onset or pace of multiple age-related changes and pathologies and also to bring the health span closer to the life span.
Keywords: Anti-aging, Anti-oxidant supplementation, Caloric restriction
Letters in Drug Design & Discovery
Title: Current Perspectives on Anti-Aging Interventions
Volume: 7 Issue: 5
Author(s): Syed Ibrahim Rizvi and Rashmi Jha
Affiliation:
Keywords: Anti-aging, Anti-oxidant supplementation, Caloric restriction
Abstract: Aging is an inherently complex process and the manifestations occur within an organism at genetic, molecular, cellular, organ, and system levels. It is now believed that aging results from a complex interplay between multiple mechanisms including oxidative stress, mitochondrial DNA damage, membrane alterations, telomere loss, apoptosis and genetic mechanisms. All the above mentioned processes contribute towards the process of aging and may underlie the age related changes. The current understanding of aging process has given novel insights in potential anti-aging interventions. The current strategies for anti-aging interventions include anti-oxidant supplementation, hormonal treatment, caloric restriction, and genetic and cellular engineering techniques. Any given intervention to be acknowledged as anti-aging must be able to demonstrate delayed onset or pace of multiple age-related changes and pathologies and also to bring the health span closer to the life span.
Export Options
About this article
Cite this article as:
Ibrahim Rizvi Syed and Jha Rashmi, Current Perspectives on Anti-Aging Interventions, Letters in Drug Design & Discovery 2010; 7 (5) . https://dx.doi.org/10.2174/157018010791163488
DOI https://dx.doi.org/10.2174/157018010791163488 |
Print ISSN 1570-1808 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-628X |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Apelin in the Control of Body Fluid Homeostasis and Cardiovascular Functions
Current Pharmaceutical Design p38 Mitogen-Activated Protein Kinase: A Critical Node Linking Insulin Resistance and Cardiovascular Diseases in Type 2 Diabetes Mellitus
Endocrine, Metabolic & Immune Disorders - Drug Targets Clinical Features of Scleroderma-Like Disorders: A Challenge for the Rheumatologist
Current Rheumatology Reviews The Prostaglandin Agonist Beraprost Aggravates Doxorubicin-mediated Apoptosis by Increasing iNOS Expression in Cardiomyocytes
Current Vascular Pharmacology Heme Oxygenase -1 Gene Therapy: Recent Advances and Therapeutic Applications
Current Gene Therapy Dynamics of T Cells Repertoire During Trypanosoma cruzi Infection and its Post-Treatment Modulation
Current Medicinal Chemistry Autoimmunity and Celiac Disease
Mini-Reviews in Medicinal Chemistry Myocardial Infarction with Non Obstructive Coronary Atherosclerosis: A Case Report
New Emirates Medical Journal Mutations of Mitochondrial DNA in Atherosclerosis and Atherosclerosis-Related Diseases
Current Pharmaceutical Design AMPK As A Target in Rare Diseases
Current Drug Targets MicroRNAs: Biomarkers for Cardiovascular Disease in Patients with Diabetes Mellitus
Current Topics in Medicinal Chemistry Cardiac Autonomic Nervous System in Heart Failure: Imaging Technique and Clinical Implications
Current Cardiology Reviews Beta-blockers in Intensive Care Medicine: Potential Benefit in Acute Brain Injury and Acute Respiratory Distress Syndrome
Recent Patents on Cardiovascular Drug Discovery Natural Products as a Paradigm for the Treatment of Coxsackievirus - induced Myocarditis
Current Topics in Medicinal Chemistry The Role of Alpha-lipoic Acid Supplementation in the Prevention of Diabetes Complications: A Comprehensive Review of Clinical Trials
Current Diabetes Reviews Epsilon Waves as an Extreme Form of Depolarization Delay: Focusing on the Arrhythmogenic Right Ventricular Cardiomyopathy/Dysplasia
Current Cardiology Reviews The Role of Negative Costimulators During Parasitic Infections
Endocrine, Metabolic & Immune Disorders - Drug Targets COVID-19 Invades Several Important Organs other than the Lungs: Organs Crosstalk
Coronaviruses New Electrocardiographic Features in Brugada Syndrome
Current Cardiology Reviews Biomarkers as a Guide of Medical Treatment in Cardiovascular Diseases
Current Medicinal Chemistry