Abstract
Currently, polycationic nanoparticles (polycation) as nonviral vectors are promising to overcome the defects of traditional viral vectors. This review focuses on the recent progress and challenges to improve the transfection efficacy and circulation time of polyplexes (complexes between polycation and pDNA or oligonucleotides such as siRNA ) in vivo.
Keywords: Gene therapy, polycation, nanoparticles, non-viral vectors, transfection efficiency, PEGylation, gene delivery, circulation time
Mini-Reviews in Medicinal Chemistry
Title: Polycationic Nanoparticles as Nonviral Vectors Employed for Gene Therapy in vivo
Volume: 10 Issue: 2
Author(s): Jinfeng Xing, Liandong Deng, Shutao Guo, Anjie Dong and Xing-Jie Liang
Affiliation:
Keywords: Gene therapy, polycation, nanoparticles, non-viral vectors, transfection efficiency, PEGylation, gene delivery, circulation time
Abstract: Currently, polycationic nanoparticles (polycation) as nonviral vectors are promising to overcome the defects of traditional viral vectors. This review focuses on the recent progress and challenges to improve the transfection efficacy and circulation time of polyplexes (complexes between polycation and pDNA or oligonucleotides such as siRNA ) in vivo.
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Cite this article as:
Xing Jinfeng, Deng Liandong, Guo Shutao, Dong Anjie and Liang Xing-Jie, Polycationic Nanoparticles as Nonviral Vectors Employed for Gene Therapy in vivo, Mini-Reviews in Medicinal Chemistry 2010; 10 (2) . https://dx.doi.org/10.2174/138955710791185127
DOI https://dx.doi.org/10.2174/138955710791185127 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
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