Abstract
It has been recently reported that thiol groups could play an important role in the protection of neuronal cells in Alzheimers disease (AD), prion disease (CJD) and Parkinsons disease (PD). Also bucillamine, that is a pseudo dipeptide possessing a thiol group capable to form an internal disulfide bridge, has relevant scavenger properties used in therapy for the treatment of arthritis. Furthermore, many sulphur containing compounds show strong chelating properties to heavy metals. Due to the crucial role of thiol groups in a variety of detoxicant biological systems, we report the synthesis of a racemic β,β-dialkyl-substituted, fully protected, cysteine derivative as a suitable intermediate in the synthesis of novel biological active peptides.
Keywords: Peptides, peptidomimetic, cysteine, thiols, β,β—dialkyl-amino acids, χ-space
Protein & Peptide Letters
Title: N-(tert)-Butyloxycarbonyl-β,β-Cyclopentyl-Cysteine (Acetamidomethyl)-Methyl Ester for Synthesis of Novel Peptidomimetic Derivatives
Volume: 17 Issue: 7
Author(s): Adriano Mollica, Federica Feliciani, Azzurra Stefanucci, Ivana Cacciatore, Catia Cornacchia, Domenica Torino and Francesco Pinnen
Affiliation:
Keywords: Peptides, peptidomimetic, cysteine, thiols, β,β—dialkyl-amino acids, χ-space
Abstract: It has been recently reported that thiol groups could play an important role in the protection of neuronal cells in Alzheimers disease (AD), prion disease (CJD) and Parkinsons disease (PD). Also bucillamine, that is a pseudo dipeptide possessing a thiol group capable to form an internal disulfide bridge, has relevant scavenger properties used in therapy for the treatment of arthritis. Furthermore, many sulphur containing compounds show strong chelating properties to heavy metals. Due to the crucial role of thiol groups in a variety of detoxicant biological systems, we report the synthesis of a racemic β,β-dialkyl-substituted, fully protected, cysteine derivative as a suitable intermediate in the synthesis of novel biological active peptides.
Export Options
About this article
Cite this article as:
Mollica Adriano, Feliciani Federica, Stefanucci Azzurra, Cacciatore Ivana, Cornacchia Catia, Torino Domenica and Pinnen Francesco, N-(tert)-Butyloxycarbonyl-β,β-Cyclopentyl-Cysteine (Acetamidomethyl)-Methyl Ester for Synthesis of Novel Peptidomimetic Derivatives, Protein & Peptide Letters 2010; 17 (7) . https://dx.doi.org/10.2174/092986610791306760
DOI https://dx.doi.org/10.2174/092986610791306760 |
Print ISSN 0929-8665 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5305 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Therapeutic Approach for Neuronal Disease by Regulating Reninangiotensin System
Current Hypertension Reviews Mediterranean Diet, Brain and Muscle: Olive Polyphenols and Resveratrol Protection in Neurodegenerative and Neuromuscular Disorders
Current Medicinal Chemistry The Promise of Slow Down Ageing May Come from Curcumin
Current Pharmaceutical Design Multivariate Optimization Model in a Partial Least Squares-1 Method for Simultaneous Determination of Dorzolamide Hydrochloride and Timolol Maleate in Eye Drops
Current Pharmaceutical Analysis Mineralocorticoid Receptor Blockade in the Protection of Target Organ Damage
Cardiovascular & Hematological Agents in Medicinal Chemistry Classification of Acetylcholinesterase Inhibitors and Decoys by a Support Vector Machine
Combinatorial Chemistry & High Throughput Screening NADPH Oxidases and Inflammatory Bowel Disease
Current Medicinal Chemistry Weight Loss in Older Persons: New Therapeutic Approaches
Current Pharmaceutical Design Multi-Target Profile of Oleocanthal, An Extra-Virgin Olive Oil Component
Current Bioactive Compounds Treatment of Periodontitis for the Prevention of Endothelial Dysfunction: A Narrative Review
Current Vascular Pharmacology Subject Index to Volume 3
Current Medicinal Chemistry - Immunology, Endocrine & Metabolic Agents Semantic Dementia: A Mini-Review
Mini-Reviews in Medicinal Chemistry Drugs of Abuse-Induced Hyperthermia, Blood-Brain Barrier Dysfunction and Neurotoxicity: Neuroprotective Effects of a New Antioxidant Compound H-290/51
Current Pharmaceutical Design Pharmacological Therapy of Parkinson’s Disease: Current Options and New Avenues
Recent Patents on CNS Drug Discovery (Discontinued) Guggulsterone for Chemoprevention of Cancer
Current Pharmaceutical Design Sleep-Disordered Breathing and Cardiovascular Disease: Exploring Pathophysiology and Existing Data
Current Respiratory Medicine Reviews Mechanisms And Prevention Of TAVI-Related Cerebrovascular Events
Current Pharmaceutical Design The Antioxidant Activities of Natural Polysaccharides
Current Drug Targets HIV-1, HCV and Alcohol in the CNS: Potential Interactions and Effects on Neuroinflammation
Current HIV Research Self-Emulsifying Drug Delivery Systems: Strategy for Improving Oral Delivery of Poorly Soluble Drugs
Current Drug Therapy