Abstract
Different imidazole derivatives were prepared by utilizing the intermediate 2-(2,4,5-triphenyl-1H-imidazol-1- yl)acetohydrazide (3) using microwave irradiation method besides the traditional ones. They were used for synthesis of some new derivatives of 2,5-disubstituted-1,3,4-oxadiazole, pyrazole, 2,5-dimethylpyrrole and nitrogen containing five membered rings. All the synthesized compounds were characterized by IR, 1H & 13C NMR and mass spectral data. The antibacterial, antifungal (MIC) and antioxidant activities were verified for all the synthesized compounds.
Keywords: 2-(2,4,5-triphenyl-1H-imidazol-1-yl)acetohydrazide, Five membered heterocycles, Microwave irradiation, Antibacterial activity, Antifungal activity, Antioxidant activity
Letters in Drug Design & Discovery
Title: Synthesis, Characterization of Some New Five Membered Heterocycles Based on Imidazole Moiety and their Applications on Therapeutics
Volume: 8 Issue: 3
Author(s): V. S.V. Satyanarayana, A. Sivakumar and Asit Ranjan Ghosh
Affiliation:
Keywords: 2-(2,4,5-triphenyl-1H-imidazol-1-yl)acetohydrazide, Five membered heterocycles, Microwave irradiation, Antibacterial activity, Antifungal activity, Antioxidant activity
Abstract: Different imidazole derivatives were prepared by utilizing the intermediate 2-(2,4,5-triphenyl-1H-imidazol-1- yl)acetohydrazide (3) using microwave irradiation method besides the traditional ones. They were used for synthesis of some new derivatives of 2,5-disubstituted-1,3,4-oxadiazole, pyrazole, 2,5-dimethylpyrrole and nitrogen containing five membered rings. All the synthesized compounds were characterized by IR, 1H & 13C NMR and mass spectral data. The antibacterial, antifungal (MIC) and antioxidant activities were verified for all the synthesized compounds.
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S.V. Satyanarayana V., Sivakumar A. and Ranjan Ghosh Asit, Synthesis, Characterization of Some New Five Membered Heterocycles Based on Imidazole Moiety and their Applications on Therapeutics, Letters in Drug Design & Discovery 2011; 8 (3) . https://dx.doi.org/10.2174/157018011794578196
DOI https://dx.doi.org/10.2174/157018011794578196 |
Print ISSN 1570-1808 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-628X |
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