Abstract
Many epidemiologic studies have demonstrated a clear association between viral bronchiolitis early in life and subsequent development of persistent wheezing. Despite that a number of studies have been conducted to reduce post-bronchiolitis wheeze, we do not have consistent evidence of an effective strategy. Two different therapeutic approaches have been evaluated: a) anti-inflammatory and/or immunomodulatory agents; and b) specific anti-viral agents. Corticosteroids have been evaluated by different routes and doses in children with RSV bronchiolitis with disappointing results. Recent data, however, suggest a potential benefit of corticosteroids in reducing the long-term wheezing associated with rhinovirus bronchiolitis. Studies evaluating the anti leukotriene receptor antagonist – montelukast — have showed inconsistent results. Finally, studies in premature infants using agents that specifically target RSV, more specifically anti-RSV antibodies (palivizumab), have provided encouraging results indicating the need to design larger studies in broader patient populations.
Keywords: RSV, asthma, steroids, monoclonal antibodies, montelukast, Bronchiolitis, wheeze, anti-inflammatory, immunomodulatory, anti-viral agents, Corticosteroids
Current Respiratory Medicine Reviews
Title: Interventions to Prevent Long-Term Consequences of Bronchiolitis
Volume: 7 Issue: 3
Author(s): Asuncion Mejias and Octavio Ramilo
Affiliation:
Keywords: RSV, asthma, steroids, monoclonal antibodies, montelukast, Bronchiolitis, wheeze, anti-inflammatory, immunomodulatory, anti-viral agents, Corticosteroids
Abstract: Many epidemiologic studies have demonstrated a clear association between viral bronchiolitis early in life and subsequent development of persistent wheezing. Despite that a number of studies have been conducted to reduce post-bronchiolitis wheeze, we do not have consistent evidence of an effective strategy. Two different therapeutic approaches have been evaluated: a) anti-inflammatory and/or immunomodulatory agents; and b) specific anti-viral agents. Corticosteroids have been evaluated by different routes and doses in children with RSV bronchiolitis with disappointing results. Recent data, however, suggest a potential benefit of corticosteroids in reducing the long-term wheezing associated with rhinovirus bronchiolitis. Studies evaluating the anti leukotriene receptor antagonist – montelukast — have showed inconsistent results. Finally, studies in premature infants using agents that specifically target RSV, more specifically anti-RSV antibodies (palivizumab), have provided encouraging results indicating the need to design larger studies in broader patient populations.
Export Options
About this article
Cite this article as:
Mejias Asuncion and Ramilo Octavio, Interventions to Prevent Long-Term Consequences of Bronchiolitis, Current Respiratory Medicine Reviews 2011; 7 (3) . https://dx.doi.org/10.2174/157339811795589496
DOI https://dx.doi.org/10.2174/157339811795589496 |
Print ISSN 1573-398X |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6387 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Sarcolemmal K<sub>ATP</sub> Channel Modulators and Cardiac Arrhythmias
Current Medicinal Chemistry Potential Cardio-Protective Agents: A Resveratrol Review (2000-2019)
Current Pharmaceutical Design Hypereosinophilic Syndrome, Churg-Strauss Syndrome and Parasitic Diseases: Possible Links between Eosinophilia and Thrombosis
Current Vascular Pharmacology Medical Treatment of Peripheral Arterial Disease: Current Concepts and Future Options
Vascular Disease Prevention (Discontinued) Safety of Systemic Biologic Agents in the Treatment of Non-malignant Skin Disorders
Current Drug Safety Synthesis and <i>In Vitro</i> Cytotoxic Evaluation of Novel Murrayafoline A Derived β-Amino Alcohols
Letters in Organic Chemistry Long-Term Bronchodilator Inhaled Therapy in COPD: The Role of Tiotropium Bromidum
Reviews on Recent Clinical Trials Modulating Mesenchymal Stromal Cell Function with Cholesterol Synthesis Inhibitors
Current Medicinal Chemistry Optimization and Assay of Antioxidant Potential of Two Penicillium spp. by Different Procedures
Current Biotechnology Co-Crystals for Generic Pharmaceuticals: An Outlook on Solid Oral Dosage Formulations
Recent Advances in Drug Delivery and Formulation Clinical Thiazolidinediones as PPARγ Ligands with the Potential for the Prevention of Cardiovascular Disease in Diabetes
Current Diabetes Reviews Maternal Nutrition and Predisposition to Later Kidney Disease
Current Drug Targets Inflammatory Biomarkers in Peripheral Artery Disease: Diagnosis, Prognosis, and Therapeutic Challenges
Current Medicinal Chemistry The Role of the Osteoprotegerin/RANKL/RANK System in Diabetic Vascular Disease
Current Medicinal Chemistry Early, Intensive and Long-term Statin Therapy in Acute Coronary Syndrome: Focus on Anti-inflammatory Mechanisms
Vascular Disease Prevention (Discontinued) Platelets as Potential Immunomodulators: Is There a Role for Platelet Toll-Like Receptors?
Current Immunology Reviews (Discontinued) Bioactivities of Iridoids
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry Percutaneous Treatment of Aortic Valve Disease: Contemporary Overview and Future Trends
Current Pharmaceutical Design Nutrigenomics and Personalized Diet: What are the Anticipated Impacts for Research on Chronic Diseases and Public Health?
Current Pharmacogenomics and Personalized Medicine Peripheral Arterial Disease in Persons with Diabetic Foot Ulceration: a Current Comprehensive Overview
Current Diabetes Reviews