Abstract
To date, Graft-versus-host disease (GVHD) represents one of the most important complications of allogeneic hematopoietic stem cell transplantation (HSCT). GVHD is one of the major determinants of transplant-related mortality and it also may be an additional cause that affects patients late outcome. Despite of the development of new and advanced Human Leukocyte Antigens (HLA) matching techniques, this complication occurs in approximately 50-80% of patients who underwent allogeneic hematopoietic stem cell transplantation, and it is responsible for one-third of deaths after transplantation. Moreover, GVHD occurrence, if moderate, may strongly contribute to the eradication of residual malignant cells which survived after myeloablative conditioning regimen, allowing the patients to have a reduced risk of relapse so that the presence of this complication may have a determinant role for the allogeneic transplantation outcome through the so-called graft-versus-tumor (GVT) effect.
Keywords: GVHD, acute, chronic, therapy, alemtuzumab, rituximab, monoclonal antibodies, Graft-versus-host disease, allogeneic, hematopoietic stem cell transplantation, HSCT, HLA, Human Leukocyte Antigens
Mini-Reviews in Medicinal Chemistry
Title: Monoclonal Antibodies to Treat Graft-Versus-Host Disease
Volume: 11 Issue: 6
Author(s): A. M. Carella, G. D'Arena and N. Cascavilla
Affiliation:
Keywords: GVHD, acute, chronic, therapy, alemtuzumab, rituximab, monoclonal antibodies, Graft-versus-host disease, allogeneic, hematopoietic stem cell transplantation, HSCT, HLA, Human Leukocyte Antigens
Abstract: To date, Graft-versus-host disease (GVHD) represents one of the most important complications of allogeneic hematopoietic stem cell transplantation (HSCT). GVHD is one of the major determinants of transplant-related mortality and it also may be an additional cause that affects patients late outcome. Despite of the development of new and advanced Human Leukocyte Antigens (HLA) matching techniques, this complication occurs in approximately 50-80% of patients who underwent allogeneic hematopoietic stem cell transplantation, and it is responsible for one-third of deaths after transplantation. Moreover, GVHD occurrence, if moderate, may strongly contribute to the eradication of residual malignant cells which survived after myeloablative conditioning regimen, allowing the patients to have a reduced risk of relapse so that the presence of this complication may have a determinant role for the allogeneic transplantation outcome through the so-called graft-versus-tumor (GVT) effect.
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Cite this article as:
M. Carella A., D'Arena G. and Cascavilla N., Monoclonal Antibodies to Treat Graft-Versus-Host Disease, Mini-Reviews in Medicinal Chemistry 2011; 11 (6) . https://dx.doi.org/10.2174/138955711795843392
DOI https://dx.doi.org/10.2174/138955711795843392 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
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