Abstract
Human leukemia results from multiple mutations that lead to abnormalities in the expressions and functions of genes that maintain the delicate balance between proliferation, differentiation and apoptosis. Continued research on the molecular aspects of leukemia cells has resulted in the developments of several potentially useful therapeutic agents. Discovery of new cellular and/or molecular pathways enabling innate or acquired resistance of cancers to current chemotherapeutics to be overcome is therefore of crucial importance if one wants to efficiently combat those cancers associated with dismal prognoses. In this concern, natural compounds are regarded as new chemical entities for the development of drugs against various pharmacological targets, including cancer, and, above all, leukemia.
Keywords: Alkaloids, leukemia, natural compounds, new drugs, polyphenols, terpenoids, mutations, abnormalities, apoptosis, chemotherapeutics
Mini-Reviews in Medicinal Chemistry
Title: Natural Compounds in Anti-Leukaemic Therapy: A Review
Volume: 11 Issue: 6
Author(s): L. De Martino, G. D'Arena, R. Filosa, A. Peduto, R. Zeppa and V. De Feo
Affiliation:
Keywords: Alkaloids, leukemia, natural compounds, new drugs, polyphenols, terpenoids, mutations, abnormalities, apoptosis, chemotherapeutics
Abstract: Human leukemia results from multiple mutations that lead to abnormalities in the expressions and functions of genes that maintain the delicate balance between proliferation, differentiation and apoptosis. Continued research on the molecular aspects of leukemia cells has resulted in the developments of several potentially useful therapeutic agents. Discovery of new cellular and/or molecular pathways enabling innate or acquired resistance of cancers to current chemotherapeutics to be overcome is therefore of crucial importance if one wants to efficiently combat those cancers associated with dismal prognoses. In this concern, natural compounds are regarded as new chemical entities for the development of drugs against various pharmacological targets, including cancer, and, above all, leukemia.
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De Martino L., D'Arena G., Filosa R., Peduto A., Zeppa R. and De Feo V., Natural Compounds in Anti-Leukaemic Therapy: A Review, Mini-Reviews in Medicinal Chemistry 2011; 11 (6) . https://dx.doi.org/10.2174/138955711795843284
DOI https://dx.doi.org/10.2174/138955711795843284 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
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