Abstract
Thioridazine is a phenothiazine drug which has previously been extensively used for its antipsychotic properties as it is associated with a low risk of extra-pyramidal side-effects. There is good evidence to suggest that, in common with other phenothiazine drugs, thioridazine has important anti-microbial activity and is a potential candidate for development as an anti-microbial drug against multi-resistant organisms, including drug-resistant strains of Mycobacterium tuberculosis. The clinical pharmacology and toxicity profile of thioridazine are reviewed in this article and the implications for future drug development along with the patent are discussed.
Keywords: Antimicrobial, cardiotoxicity, extra-pyramidal syndrome, QT prolongation, thioridazine, METABOLISM OF THIORIDAZINE, CYP2C19, Anti-psychotic activity, arrhythmogenic effect
Recent Patents on Anti-Infective Drug Discovery
Title: Thioridazine: The Good and the Bad
Volume: 6 Issue: 2
Author(s): Ruben H.K. Thanacoody
Affiliation:
Keywords: Antimicrobial, cardiotoxicity, extra-pyramidal syndrome, QT prolongation, thioridazine, METABOLISM OF THIORIDAZINE, CYP2C19, Anti-psychotic activity, arrhythmogenic effect
Abstract: Thioridazine is a phenothiazine drug which has previously been extensively used for its antipsychotic properties as it is associated with a low risk of extra-pyramidal side-effects. There is good evidence to suggest that, in common with other phenothiazine drugs, thioridazine has important anti-microbial activity and is a potential candidate for development as an anti-microbial drug against multi-resistant organisms, including drug-resistant strains of Mycobacterium tuberculosis. The clinical pharmacology and toxicity profile of thioridazine are reviewed in this article and the implications for future drug development along with the patent are discussed.
Export Options
About this article
Cite this article as:
H.K. Thanacoody Ruben, Thioridazine: The Good and the Bad, Recent Patents on Anti-Infective Drug Discovery 2011; 6 (2) . https://dx.doi.org/10.2174/157489111796064588
DOI https://dx.doi.org/10.2174/157489111796064588 |
Print ISSN 1574-891X |
Publisher Name Bentham Science Publisher |
Online ISSN 2212-4071 |
Related Articles
-
Patent Selections:
Recent Patents on Anti-Infective Drug Discovery Advances of Bioinformatics Applied to Development and Evaluation of Boron-Containing Compounds
Current Organic Chemistry Natural T Cell Immunity to Intracellular Pathogens and Nonpeptidic Immunoregulatory Drugs
Current Molecular Medicine Lymphadenopathy as a Prodrome for Systemic Lupus Erythematous
Current Rheumatology Reviews Design, Synthesis and Antimycobacterial Activity of Some New Azaheterocycles: Phenanthroline with p-halo-benzoyl Skeleton. Part V
Letters in Drug Design & Discovery Morbidity and Mortality Associated with Pharmacotherapy. Evolution and Current Concept of Drug-Related Problems
Current Pharmaceutical Design Human N-Acetyltransferases and Drug-Induced Hepatotoxicity
Current Drug Metabolism Use of Corticosteroids in Critically Ill Septic Patients: A Review of Mechanisms of Adrenal Insufficiency in Sepsis and Treatment
Current Drug Targets Virtual Screening on Analogs of 2 Methyl Heptyl Isonicotinate as GlmU Inhibitors of Mycobacterium tuberculosis
Current Enzyme Inhibition Increment of Antimycobaterial Activity on Lichexanthone Derivatives
Medicinal Chemistry Probiotics/Prebiotics in Viral Respiratory Infections: Implication for Emerging Pathogens
Recent Patents on Biotechnology Targeting the Folate Receptor: Improving Efficacy in Inorganic Medicinal Chemistry
Current Medicinal Chemistry Structure-Based Approaches to Drug Discovery Against Tuberculosis
Current Protein & Peptide Science Opportunities and Challenges for Host-Directed Therapies in Tuberculosis
Current Pharmaceutical Design Tumor Necrosis Factor Inhibitors in Pediatric Asthma
Recent Patents on Inflammation & Allergy Drug Discovery Analysis of Capsaicinoids in Hot Sauces Using a Silica Hydride-Based Stationary Phase
Current Chromatography Small Heat Shock Proteins and Protein-Misfolding Diseases
Current Pharmaceutical Biotechnology An Update on the Management of Severe Cutaneous Drug Hypersensitivity Reactions
Current Pharmaceutical Design Tuberculosis and Diabetes Mellitus Co-morbidity
Current Respiratory Medicine Reviews A Comprehensive Review on Recent advances in Synthesis & Pharmacotherapeutic potential of Benzothiazoles
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry