Abstract
Intractable epilepsy can have a detrimental impact on children, increasing the likelihood of developmental delays and cognitive dysfunction, and negatively impacting quality of life. The goals of surgical intervention in pediatric epilepsy are multifactorial and include optimal seizure control and/or remission, improvement of functionality, and facilitation of brain development. Several factors contribute to post-surgical outcomes in children, which will be discussed in this article. Research findings suggest that surgical treatment can have a positive effect beyond seizure control, including improvements in cognition, academic skills, neurobehavioral functioning, and emotional state. An important emerging theme in the presented studies is advocacy for early surgical intervention in children. Future expansion of research in long-term pediatric surgery outcomes is necessary, especially regarding epilepsy in posterior brain regions, effect on academic performance, and impact on overall quality of life following surgery. Advances in structural and functional neuroimaging will contribute to greater understanding of the relationship between outcomes and plasticity.
Keywords: Cognitive, epilepsy, neuropsychology, pediatric, psychosocial, outcomes, surgery
Current Pediatric Reviews
Title: Pediatric Epilepsy Surgery: Neuropsychological and Psychosocial Outcomes
Volume: 8 Issue: 1
Author(s): Jacqueline Phillips-Sabol, Daniel Cruz-Laureano, Anna E. Pineda-Olvera, Bethany Williams and J. Gregory Westhafer
Affiliation:
Keywords: Cognitive, epilepsy, neuropsychology, pediatric, psychosocial, outcomes, surgery
Abstract: Intractable epilepsy can have a detrimental impact on children, increasing the likelihood of developmental delays and cognitive dysfunction, and negatively impacting quality of life. The goals of surgical intervention in pediatric epilepsy are multifactorial and include optimal seizure control and/or remission, improvement of functionality, and facilitation of brain development. Several factors contribute to post-surgical outcomes in children, which will be discussed in this article. Research findings suggest that surgical treatment can have a positive effect beyond seizure control, including improvements in cognition, academic skills, neurobehavioral functioning, and emotional state. An important emerging theme in the presented studies is advocacy for early surgical intervention in children. Future expansion of research in long-term pediatric surgery outcomes is necessary, especially regarding epilepsy in posterior brain regions, effect on academic performance, and impact on overall quality of life following surgery. Advances in structural and functional neuroimaging will contribute to greater understanding of the relationship between outcomes and plasticity.
Export Options
About this article
Cite this article as:
Phillips-Sabol Jacqueline, Cruz-Laureano Daniel, E. Pineda-Olvera Anna, Williams Bethany and Gregory Westhafer J., Pediatric Epilepsy Surgery: Neuropsychological and Psychosocial Outcomes, Current Pediatric Reviews 2012; 8 (1) . https://dx.doi.org/10.2174/157339612799746290
DOI https://dx.doi.org/10.2174/157339612799746290 |
Print ISSN 1573-3963 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6336 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
GABAB Receptors-Associated Proteins: Potential Drug Targets in Neurological Disorders?
Current Drug Targets Dreams and Psychedelics: Neurophenomenological Comparison and Therapeutic Implications
Current Neuropharmacology A Review on Possible Therapeutic Effect of Nigella sativa and Thymoquinone in Neurodegenerative Diseases
CNS & Neurological Disorders - Drug Targets Anticonvulsant Action and Long-term Effects of Gabapentin
Current Neuropharmacology Editorial [Hot topic: Pharmacotherapies for Alcoholism: The Old and the New (Guest Editor: M. Foster Olive)]
CNS & Neurological Disorders - Drug Targets Renin-Angiotensin System in Central Nervous System Diseases and its Interaction with COVID-19
Current Medicinal Chemistry Is the Modulation of Autophagy the Future in the Treatment of Neurodegenerative Diseases?
Current Topics in Medicinal Chemistry A Review on Chitosan in Drug Delivery for Treatment of Neurological and Psychiatric Disorders
Current Pharmaceutical Biotechnology Anticonvulsant and Antitubercular Activities of 6-Phenyl/Biphenyl-4-yl-2- [2-(pyridin-2-ylamino)-ethyl]- and 6-(Biphenyl-4yl)-2-(2N-subtituted amin- 1-yl)-ethyl derivatives of 4,5-dihydropyridazin-3(2H)-one
Letters in Drug Design & Discovery Novel Approaches Towards Designing of Isoform-Selective Inhibitors Against Class II Histone Deacetylases: The Acute Requirement for Targetted Anticancer Therapy
Current Topics in Medicinal Chemistry From Discovery to the Coming Generation of Histone Deacetylase Inhibitors
Current Medicinal Chemistry The Role of Oxazolidine Derivatives in the Treatment of Infectious and Chronic Diseases
Current Bioactive Compounds Design, Synthesis, Characterization, Molecular Docking, ADME Properties and <i>In Vivo</i> Antipsychotic Activity of Aripiprazole Related Drugs Candidates
Letters in Drug Design & Discovery Liverworts-Potential Source of Medicinal Compounds
Current Pharmaceutical Design Inhibitors of HDACs - Effective Drugs Against Cancer?
Current Cancer Drug Targets Neuropharmacology of Cannabinoid System: From Basic Science to Clinical Applications
Current Neuropharmacology The Therapeutic Aspects of the Endocannabinoid System (ECS) for Cancer and their Development: From Nature to Laboratory
Current Pharmaceutical Design The Contribution of DTI in Determining the Relationship of Epilepsy and Brain Lesions in Children with Tuberous Sclerosis
Current Medical Imaging Targeted Blood-to-Brain Drug Delivery – 10 Key Development Criteria
Current Pharmaceutical Biotechnology The Interplay Among Epilepsy, Parkinson’s Disease and Inflammation: Revisiting the Link through Ca<sup>2+</sup>/cAMP Signalling
Current Neurovascular Research