Abstract
The availability of complete genome sequences and the wealth of large-scale biological datasets provide an unprecedented opportunity to elucidate the genetic basis of human diseases. Therapeutically relevant targets should be both ‘druggable’ and ‘disease modifying’. In this review we examine the application of computational biology towards the exploration of druggability, targetability and evolutionary conservation of human disease genes. These analyses could have a tremendous potential for systematic in silico drug target identification in the post-genomic era.
Keywords: Disease genes, drugs, target, model organisms
Current Drug Discovery Technologies
Title: Targetability of Human Disease Genes
Volume: 4 Issue: 1
Author(s): Meena K. Sakharkar and Kishore R. Sakharkar
Affiliation:
Keywords: Disease genes, drugs, target, model organisms
Abstract: The availability of complete genome sequences and the wealth of large-scale biological datasets provide an unprecedented opportunity to elucidate the genetic basis of human diseases. Therapeutically relevant targets should be both ‘druggable’ and ‘disease modifying’. In this review we examine the application of computational biology towards the exploration of druggability, targetability and evolutionary conservation of human disease genes. These analyses could have a tremendous potential for systematic in silico drug target identification in the post-genomic era.
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Cite this article as:
Meena K. Sakharkar and Kishore R. Sakharkar , Targetability of Human Disease Genes, Current Drug Discovery Technologies 2007; 4 (1) . https://dx.doi.org/10.2174/157016307781115494
DOI https://dx.doi.org/10.2174/157016307781115494 |
Print ISSN 1570-1638 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6220 |
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