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Drug Metabolism Letters

Editor-in-Chief

ISSN (Print): 1872-3128
ISSN (Online): 1874-0758

Antioxidants Suppress Th1-Type Immune Response In Vitro

Author(s): Katharina Schroecksnadel, Birgit Fischer, Harald Schennach, Guenter Weiss and Dietmar Fuchs

Volume 1, Issue 3, 2007

Page: [166 - 171] Pages: 6

DOI: 10.2174/187231207781369816

Price: $65

Abstract

Inflammation is a hallmark of various diseases like infections, autoimmune syndromes, cardiovascular and neurodegenerative disorders, and cancer. Thereby, Th1-type cytokine interferon-γ is a central pro-inflammatory mediator. Antioxidant compounds counteract the activation of T-cells and macrophages. This anti-inflammatory activity could be important for the development of immunotolerance and for treatment of above-mentioned disorders.

Keywords: Antioxidants, inflammation, neopterin, indoleamine (2,3)-dioxygenase, interferon-γ

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