Complement: An Inflammatory Pathway Fulfilling Multiple Roles at the Interface of Innate Immunity and Development

Title: Complement: An Inflammatory Pathway Fulfilling Multiple Roles at the Interface of Innate Immunity and Development

Volume: 4 Issue: 1

Author(s): D. Mastellos, A. E. Germenis and J. D. Lambris

Affiliation:

Keywords: Immunity, proteins, multiorgan

Abstract: Complement has been long perceived as an innate immune system that plays a pivotal role in the maintenance of host defense against infectious agents and the propagation of pro-inflammatory responses in the context of human disease. Complement activation has been associated with the onset of acute inflammatory reactions leading to complications such as acute graft rejection, local tissue injury and multiorgan failure. However, recent studies have indicated that various complement activation products may exert a beneficial effect by contributing

Cite this article as:

Mastellos D., Germenis E. A. and Lambris D. J., Complement: An Inflammatory Pathway Fulfilling Multiple Roles at the Interface of Innate Immunity and Development, Current Drug Targets - Inflammation & Allergy 2005; 4 (1) . https://dx.doi.org/10.2174/1568010053622993