Abstract
Leptin was originally identified as an adipocyte-derived cytokine with a key role in the regulation of the energy balance. Subsequent research has, however, revealed that leptins biological action is not restricted to its effects on appetite and food intake, but rather has a much more pleiotropic character. Evidence is now accumulating that it has important functions in reproduction, hematopoiesis, HPA-axis endocrinology and angiogenesis. In this review, we have focused on the effects of leptin in the immune system, which can be found in both the antigen-specific immunity and in the inflammatory effector system.
Keywords: Leptin, Systemic Inflammatory Response Syndrome (SIRS), Immune Response, STARVATION, CELL IMMUNITY
Current Drug Targets - Inflammation & Allergy
Title: A Role for Leptin in the Systemic Inflammatory Response Syndrome (SIRS) and in Immune Response
Volume: 1 Issue: 3
Author(s): W. Waelput, P. Brouckaert, D. Broekaert and J. Tavernier
Affiliation:
Keywords: Leptin, Systemic Inflammatory Response Syndrome (SIRS), Immune Response, STARVATION, CELL IMMUNITY
Abstract: Leptin was originally identified as an adipocyte-derived cytokine with a key role in the regulation of the energy balance. Subsequent research has, however, revealed that leptins biological action is not restricted to its effects on appetite and food intake, but rather has a much more pleiotropic character. Evidence is now accumulating that it has important functions in reproduction, hematopoiesis, HPA-axis endocrinology and angiogenesis. In this review, we have focused on the effects of leptin in the immune system, which can be found in both the antigen-specific immunity and in the inflammatory effector system.
Export Options
About this article
Cite this article as:
Waelput W., Brouckaert P., Broekaert D. and Tavernier J., A Role for Leptin in the Systemic Inflammatory Response Syndrome (SIRS) and in Immune Response, Current Drug Targets - Inflammation & Allergy 2002; 1 (3) . https://dx.doi.org/10.2174/1568010023344634
DOI https://dx.doi.org/10.2174/1568010023344634 |
Print ISSN 1568-010X |
Publisher Name Bentham Science Publisher |
Online ISSN 1568-010X |
Related Articles
-
Humanized Mouse Models of HIV-1 Latency
Current HIV Research Bench to Bedside Targeting of FLT3 in Acute Leukemia
Current Drug Targets Modulation of Individual Susceptibility to the No-Reflow Phenomenon after Acute Myocardial Infarction
Current Pharmaceutical Design Mesalamine for Inflammatory Bowel Disease: Recent Reappraisals
Inflammation & Allergy - Drug Targets (Discontinued) Circulating Matrix Metalloproteinase-9 Levels in Patients with Systemic Lupus Erythematosus: A Meta-analysis
Current Pharmaceutical Design Association of Oxidative Stress with Neurological Disorders
Current Neuropharmacology Synthesis and Biological Potential Assessment of 2-Substituted Quinazolin-4(3<i>H</i>)-ones as Inhibitors of Phosphodiesterase-I and Carbonic Anhydrase-II
Medicinal Chemistry Drotrecogin Alfa (Activated) in the Treatment of Severe Sepsis
Current Drug Safety Obesity: The Metabolic Disease, Advances on Drug Discovery and Natural Product Research
Current Topics in Medicinal Chemistry The Effect of Cyclosporine A on Dermal Fibroblast Cell - Transcriptomic Analysis of Inflammatory Response Pathway
Current Pharmaceutical Biotechnology Drug-Induced Nephrotoxicity: Pathogenic Mechanisms, Biomarkers and Prevention Strategies
Current Drug Metabolism Polyphenols: A Nutraceutical Approach Against Diseases
Recent Patents on Food, Nutrition & Agriculture Fused Xanthone Derivatives as Antiproliferative Agents
Anti-Cancer Agents in Medicinal Chemistry Immuno-Isolation in Cancer Gene Therapy
Current Gene Therapy Aspirin Hypersensitivity in Patients Undergoing Percutaneous Coronary Intervention. What Should We be Doing?
Current Vascular Pharmacology Oxidative Stress-Induced Ischemic Heart Disease: Protection by Antioxidants
Current Medicinal Chemistry Development and Validation of a UPLC-MS/MS Method for the Simultaneous Determination of Verapamil and Trandolapril in Rat Plasma: Application to a Pharmacokinetic Study
Current Pharmaceutical Analysis Mif1: A Missing Link between the Unfolded Protein Response Pathway and ER-Associated Protein Degradation?
Current Protein & Peptide Science Computational Protein Design: A Novel Path to Future Protein Drugs
Current Pharmaceutical Design Inactivation of Parathyroid Hormone: Perspectives of Drug Discovery to Combating Hyperparathyroidism
Current Molecular Pharmacology