Abstract
The HIV-1 Rev protein, which traffics through nucleolus and shuttles between nucleus and cytoplasm, facilitates export of unspliced and singly spliced viral transcripts containing RRE RNA by the CRM1 export pathway. Inhibitions of the various stages of Rev-mediated RNA transport can arrest HIV-1 transcriptional process. The current understanding to the mechanism of Rev function, Rev-RRE interaction, as well as inhibitors hereof is reviewed.
Keywords: AIDS, HIV-1, transcription, inhibitors, Rev, RRE, antiviral
Current HIV Research
Title: Cessation of HIV-1 Transcription by Inhibiting Regulatory Protein Rev- Mediated RNA Transport
Volume: 7 Issue: 1
Author(s): Yuan Cao, Xinyong Liu and Erik De Clercq
Affiliation:
Keywords: AIDS, HIV-1, transcription, inhibitors, Rev, RRE, antiviral
Abstract: The HIV-1 Rev protein, which traffics through nucleolus and shuttles between nucleus and cytoplasm, facilitates export of unspliced and singly spliced viral transcripts containing RRE RNA by the CRM1 export pathway. Inhibitions of the various stages of Rev-mediated RNA transport can arrest HIV-1 transcriptional process. The current understanding to the mechanism of Rev function, Rev-RRE interaction, as well as inhibitors hereof is reviewed.
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Cite this article as:
Cao Yuan, Liu Xinyong and De Clercq Erik, Cessation of HIV-1 Transcription by Inhibiting Regulatory Protein Rev- Mediated RNA Transport, Current HIV Research 2009; 7 (1) . https://dx.doi.org/10.2174/157016209787048564
DOI https://dx.doi.org/10.2174/157016209787048564 |
Print ISSN 1570-162X |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4251 |
Call for Papers in Thematic Issues
HIV vaccine development
The development of a safe and effective vaccine that impedes HIV-1 transmission and/or limits the severity of infection remains a public health priority. The HIV-1/AIDS pandemic continues to have a disproportionate impact on vulnerable and under-served communities in the USA and globally. In the USA, minority communities that have relatively ...read more
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