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Current Chemical Biology

Editor-in-Chief

ISSN (Print): 2212-7968
ISSN (Online): 1872-3136

Advances in the Development of Virus-Like Particles as Tools in Medicine and Nanoscience

Author(s): Sandra Paola Sanchez-Rodriguez, Lucia Munch-Anguiano and Ismael Bustos-Jaimes

Volume 4, Issue 3, 2010

Page: [231 - 243] Pages: 13

DOI: 10.2174/2212796811004030231

Price: $65

Abstract

Virus-like particles (VLPs) are viral coats formed by the self-assembly of the components of viruses excluding their genetic material. These particles may be used as vectors to transport molecules chemically attached on the VLP surface, or as vessels for the systemic delivery of pharmacologically important molecules as drugs, siRNAs, genes, mRNAs, magnetic nanoparticles, quantum dots and other medical-imaging aids. Herein we review the recent advances in heterologous production and purification of VLPs, the current trends in chemical modification of VLPs, and the advances on the application of VLPs as vectors, tools for medical imaging and materials for nanotechnology.

Keywords: Virus-like particles, nanomaterials, nanomedicine, drug delivery, gene delivery, imaging


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