Abstract
Nanoemulsions are composed of nanoscale droplets of one immiscible liquid dispersed within another, which have been the focus of extensive research worldwide due to their solubilization and transportation capacity of both hydrophobic and hydrophilic active compounds with unique physical properties. In a broad sense, submicron-emulsion, microemulsion, self-microemulsifing drug delivery system, lipid emulsion and cholesterol-rich microemulsion (LDE) all belong to nanoemulsions. The review starts with a brief introduction to the definition, formulation rationale, and types of nanoemulaions, and focused on, by different administration routes such as the oral, intravenous, transdermal, ocular nasal and rectal routes, the absorption, disposition, pharmacokinetics properties of nanoemulsions.
Keywords: Nanoemulsion, microemulsion, SMEDDS, absorption, pharmacokinetics, disposition
Current Drug Metabolism
Title:Absorption, Disposition and Pharmacokinetics of Nanoemulsions
Volume: 13 Issue: 4
Author(s): Yi Lu, Jianping Qi and Wei Wu
Affiliation:
Keywords: Nanoemulsion, microemulsion, SMEDDS, absorption, pharmacokinetics, disposition
Abstract: Nanoemulsions are composed of nanoscale droplets of one immiscible liquid dispersed within another, which have been the focus of extensive research worldwide due to their solubilization and transportation capacity of both hydrophobic and hydrophilic active compounds with unique physical properties. In a broad sense, submicron-emulsion, microemulsion, self-microemulsifing drug delivery system, lipid emulsion and cholesterol-rich microemulsion (LDE) all belong to nanoemulsions. The review starts with a brief introduction to the definition, formulation rationale, and types of nanoemulaions, and focused on, by different administration routes such as the oral, intravenous, transdermal, ocular nasal and rectal routes, the absorption, disposition, pharmacokinetics properties of nanoemulsions.
Export Options
About this article
Cite this article as:
Lu Yi, Qi Jianping and Wu Wei, Absorption, Disposition and Pharmacokinetics of Nanoemulsions, Current Drug Metabolism 2012; 13 (4) . https://dx.doi.org/10.2174/138920012800166544
DOI https://dx.doi.org/10.2174/138920012800166544 |
Print ISSN 1389-2002 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5453 |
Call for Papers in Thematic Issues
Interaction between drugs and endocrine diseases
The introduction of highly active antiretroviral therapy accelerated studies and our understanding on the interaction between pharmacological therapies and endocrine diseases. Drugs can precipitate endocrine via different mechanisms, including direct alteration of hormone production and secretion, dysregulation of hormonal axis, effects on hormonal transport, receptor-binding, and cellular signalling. Common drug-induced ...read more
Related Journals
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Tea (Camellia sinensis (L.)): A Putative Anticancer Agent in Bladder Carcinoma?
Anti-Cancer Agents in Medicinal Chemistry Apoptosis-Inducing Activity and Antiproliferative Effect of Gossypin on PC-3 Prostate Cancer Cells
Anti-Cancer Agents in Medicinal Chemistry CXCR4-targeted Nanoparticles Reduce Cell Viability, Induce Apoptosis and Inhibit SDF-1α Induced BT-549-Luc Cell Migration In Vitro
Current Drug Delivery Immune and Genetic Mechanisms in COPD: Possible Targets for Therapeutic Interventions
Current Drug Targets Molecular Mechanisms of Anti-cancer Activities of β-elemene: Targeting Hallmarks of Cancer
Anti-Cancer Agents in Medicinal Chemistry Recent Advances in the Synthesis of Bioactive Quinoline-Based 1,2,3-Triazoles via Cu-Catalyzed Huisgen 1,3-Dipolar Cycloaddition (“Click Reaction”)
Mini-Reviews in Organic Chemistry Therapeutic Benefit and Biological Importance of Ginkgetin in the Medicine: Medicinal Importance, Pharmacological Activities and Analytical Aspects
Current Bioactive Compounds Effects of PPARγ Ligands on Vascular Tone
Current Molecular Pharmacology Targeting the Akt Kinase to Modulate Survival, Invasiveness and Drug Resistance of Cancer Cells
Current Medicinal Chemistry Metastatic Colorectal Cancer: Role of Target Therapies and Future Perspectives
Current Cancer Drug Targets The Role of Anionic Polysaccharides in the Preparation of Nanomedicines with Anticancer Applications
Current Pharmaceutical Design Glycerophospholipid Synthesis as a Novel Drug Target Against Cancer
Current Molecular Pharmacology Small Molecule CXCR4 Chemokine Receptor Antagonists: Developing Drug Candidates
Current Medicinal Chemistry Anti-Angiogenic and Anti-Inflammatory Effects of Statins: Relevance to Anti-Cancer Therapy
Current Cancer Drug Targets Methoxychalcones: Effect of Methoxyl Group on the Antifungal, Antibacterial and Antiproliferative Activities
Medicinal Chemistry Tyrosine Kinase Blockers: New Hope for Successful Cancer Therapy
Anti-Cancer Agents in Medicinal Chemistry Patent Selections
Recent Patents on DNA & Gene Sequences Signaling Transduction Network Mediated by Tumor Suppressor/Susceptibility Genes in NPC
Current Genomics Evaluation of the in vitro Chemosensitivity and Correlation with Clinical Outcomes in Lung Cancer using the ATP-TCA
Anti-Cancer Agents in Medicinal Chemistry OX40 and OX40L Interaction in Cancer
Current Medicinal Chemistry