Abstract
Most cell types can release vesicles. Cell-derived vesicles are increasingly recognized as an evolutionary wide-spread mechanism of intercellular communication. The paracrine and long range activity of vesicles and their regulated cargo-composition endows these vesicles with regulatory properties beyond that of the parental cell. The release and biogenesis of cell-derived vesicles is a dynamic and tightly controlled process. In the past years it has become clear that these vesicles exert a plethora of biological effects. This has sparked the intense interest in these vesicles in relation to (patho)physiological processes. This review focuses on the role of cell-derived vesicles in inflammation, with emphasis on the immune modulating capacity of immune cell-derived vesicles. The biological activity of different leukocyte-derived vesicles is compared, and potential explanations for the strong biological effects exhibited by vesicles are provided. The role of cell-derived vesicles in inflammatory processes is discussed by speculating how these vesicles can contribute to allergic inflammation.
Keywords: Exosome, microvesicle, microparticle, membrane vesicle, ectosome, allergy, immune regulation, immune cells
Current Pharmaceutical Design
Title:Immune Cell-derived Vesicles: Modulators and Mediators of Inflammation
Volume: 18 Issue: 16
Author(s): Esther N.M. Nolte-‘t Hoen and Marca H.M. Wauben
Affiliation:
Keywords: Exosome, microvesicle, microparticle, membrane vesicle, ectosome, allergy, immune regulation, immune cells
Abstract: Most cell types can release vesicles. Cell-derived vesicles are increasingly recognized as an evolutionary wide-spread mechanism of intercellular communication. The paracrine and long range activity of vesicles and their regulated cargo-composition endows these vesicles with regulatory properties beyond that of the parental cell. The release and biogenesis of cell-derived vesicles is a dynamic and tightly controlled process. In the past years it has become clear that these vesicles exert a plethora of biological effects. This has sparked the intense interest in these vesicles in relation to (patho)physiological processes. This review focuses on the role of cell-derived vesicles in inflammation, with emphasis on the immune modulating capacity of immune cell-derived vesicles. The biological activity of different leukocyte-derived vesicles is compared, and potential explanations for the strong biological effects exhibited by vesicles are provided. The role of cell-derived vesicles in inflammatory processes is discussed by speculating how these vesicles can contribute to allergic inflammation.
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Cite this article as:
N.M. Nolte-‘t Hoen Esther and H.M. Wauben Marca, Immune Cell-derived Vesicles: Modulators and Mediators of Inflammation, Current Pharmaceutical Design 2012; 18 (16) . https://dx.doi.org/10.2174/138161212800166013
DOI https://dx.doi.org/10.2174/138161212800166013 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
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