Abstract
Genistein is the most abundant isoflavone in soybeans. It has exhibited diverse biological activities, among these, its anticancer effects is most noteworthy. Through regulating critical cell cycle genes, genistein can inhibit cancer cell growth in vivo and in vitro. It has been reported that genistein can inhibit activation of NF-κB and Akt signaling pathways to induce cell apopt1osis, both pathways are well known for their function to maintain a balance between cell survival and apoptosis. In order to find out more outstanding anticancer isoflavone agents, against cancers extended synthesis of genistein derivatives has been carried out. Some of these synthetic compounds demonstrated higher anticancer activity with lower doses. Based on these results, genistein and its synthetic derivatives may be an emerging new type of anticancer agents.
Keywords: genistein, isoflavone, derivative, anticancer, molecular mechanisms, signaling pathways, catechins, anthocyanidins, proanthocyanidins, chemoprevention
Mini-Reviews in Medicinal Chemistry
Title:The Mechanisms of Anticancer Agents by Genistein and Synthetic Derivatives of Isoflavone
Volume: 12 Issue: 4
Author(s): H.-Q. Li, Y. Luo, C.-H. Qiao
Affiliation:
Keywords: genistein, isoflavone, derivative, anticancer, molecular mechanisms, signaling pathways, catechins, anthocyanidins, proanthocyanidins, chemoprevention
Abstract: Genistein is the most abundant isoflavone in soybeans. It has exhibited diverse biological activities, among these, its anticancer effects is most noteworthy. Through regulating critical cell cycle genes, genistein can inhibit cancer cell growth in vivo and in vitro. It has been reported that genistein can inhibit activation of NF-κB and Akt signaling pathways to induce cell apopt1osis, both pathways are well known for their function to maintain a balance between cell survival and apoptosis. In order to find out more outstanding anticancer isoflavone agents, against cancers extended synthesis of genistein derivatives has been carried out. Some of these synthetic compounds demonstrated higher anticancer activity with lower doses. Based on these results, genistein and its synthetic derivatives may be an emerging new type of anticancer agents.
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Cite this article as:
H.-Q. Li, Y. Luo, C.-H. Qiao , The Mechanisms of Anticancer Agents by Genistein and Synthetic Derivatives of Isoflavone, Mini-Reviews in Medicinal Chemistry 2012; 12 (4) . https://dx.doi.org/10.2174/138955712799829258
DOI https://dx.doi.org/10.2174/138955712799829258 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
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