Abstract
The literature data confirm that membrane rafts are required for the proper organization of signalling pathway within lung parenchyma. The physiological role of membrane rafts appears to be closely linked to their ability to modulate contraction, cell proliferation, matrix protein and mediator production by airway mesenchymal and airway/alveolar epithelial cells.
In particular, the data obtained in endothelial cells suggest that in membrane rafts signalling complexes are assembled allowing a rapid, efficient and regulated response to extracellular stimuli. In fact, the presence of caveolae and Cav-1 is required in endothelial cells for short and long term mechano-transduction in blood vessels. The endothelium lacking caveolae is unable to couple changes in blood flow with proportional vascular remodeling, suggesting that caveolae might represent an initial flow mechano-sensor directly regulated by luminal blood flow. It is evident that membrane rafts, particularly caveolae, play critical roles in several cell types present in the lung and the aberrant regulation of caveolin expression may trigger pulmonary defects, including pulmonary hypertension, inflammation and fibros
A better understanding of dynamics of caveolae in transmembrane traffic in the lung might be of specific interest in drug targeting delivery.
Keywords: Caveolae, lipid rafts, pulmonary hypertension, edema, fibrosis and inflammation
Current Respiratory Medicine Reviews
Title:Membrane Rafts in the Respiratory System
Volume: 8 Issue: 2
Author(s): Paola Palestini, Diana Cunati, Francesca Farina, Laura Botto
Affiliation:
Keywords: Caveolae, lipid rafts, pulmonary hypertension, edema, fibrosis and inflammation
Abstract: The literature data confirm that membrane rafts are required for the proper organization of signalling pathway within lung parenchyma. The physiological role of membrane rafts appears to be closely linked to their ability to modulate contraction, cell proliferation, matrix protein and mediator production by airway mesenchymal and airway/alveolar epithelial cells.
In particular, the data obtained in endothelial cells suggest that in membrane rafts signalling complexes are assembled allowing a rapid, efficient and regulated response to extracellular stimuli. In fact, the presence of caveolae and Cav-1 is required in endothelial cells for short and long term mechano-transduction in blood vessels. The endothelium lacking caveolae is unable to couple changes in blood flow with proportional vascular remodeling, suggesting that caveolae might represent an initial flow mechano-sensor directly regulated by luminal blood flow. It is evident that membrane rafts, particularly caveolae, play critical roles in several cell types present in the lung and the aberrant regulation of caveolin expression may trigger pulmonary defects, including pulmonary hypertension, inflammation and fibros
A better understanding of dynamics of caveolae in transmembrane traffic in the lung might be of specific interest in drug targeting delivery.
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Cite this article as:
Paola Palestini, Diana Cunati, Francesca Farina, Laura Botto , Membrane Rafts in the Respiratory System, Current Respiratory Medicine Reviews 2012; 8 (2) . https://dx.doi.org/10.2174/157339812799859815
DOI https://dx.doi.org/10.2174/157339812799859815 |
Print ISSN 1573-398X |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6387 |
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