Abstract
Tripterygium wilfordii Hook.f. has a long history of use in traditional Chinese medicine. The diterpene triepoxide triptolide 1, as the main bioactive constituent of Tripterygium extracts, has been used to treat a variety of autoimmune, inflammation-related conditions and neurodegenerative diseases, and it also displays antiinflammatory activity, antiproliferative and apoptotic effects, antifertility and insecticidal activity. Several synthetic studies and structure-activity relationships (SAR) have been carried out on triptolide as well as others structurally related molecules. This review focused on the biological and pharmacological activities, total syntheses and their structure-activity relationships of triptolide and congeners.
Keywords: Tripterygium, Triptolide, Diterpene, Antiinflammatory, Anticancer, Spondylitis, Systemic lupus erythematosus, TWHF, iNOS, Tamelens method, Alvarez-manzanedas method, Lactone ring
Mini-Reviews in Organic Chemistry
Title:Bio-Activities and Syntheses Developments of Triptolides
Volume: 9 Issue: 2
Author(s): Shi-Wu Chen, Ni-Ni Zhou and Chong Li
Affiliation:
Keywords: Tripterygium, Triptolide, Diterpene, Antiinflammatory, Anticancer, Spondylitis, Systemic lupus erythematosus, TWHF, iNOS, Tamelens method, Alvarez-manzanedas method, Lactone ring
Abstract: Tripterygium wilfordii Hook.f. has a long history of use in traditional Chinese medicine. The diterpene triepoxide triptolide 1, as the main bioactive constituent of Tripterygium extracts, has been used to treat a variety of autoimmune, inflammation-related conditions and neurodegenerative diseases, and it also displays antiinflammatory activity, antiproliferative and apoptotic effects, antifertility and insecticidal activity. Several synthetic studies and structure-activity relationships (SAR) have been carried out on triptolide as well as others structurally related molecules. This review focused on the biological and pharmacological activities, total syntheses and their structure-activity relationships of triptolide and congeners.
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Chen Shi-Wu, Zhou Ni-Ni and Li Chong, Bio-Activities and Syntheses Developments of Triptolides, Mini-Reviews in Organic Chemistry 2012; 9 (2) . https://dx.doi.org/10.2174/157019312800604661
DOI https://dx.doi.org/10.2174/157019312800604661 |
Print ISSN 1570-193X |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6298 |
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