Abstract
After binding to the neurokinin-1 (NK-1) receptor, substance P (SP) induces tumor cell proliferation, angiogenesis, and the migration of tumor cells for invasion and metastasis. After binding to NK-1 receptors, NK-1 receptor antagonists inhibit tumor cell proliferation, angiogenesis and the migration of tumor cells. These antagonists are broad-spectrum antitumor drugs. In addition, in the host they display beneficial effects: anxiolytic, antiemetic, neuroprotector, nephroprotector, hepatoprotector, antiinflammatory and analgesic. In combination therapy with classic cytostatics, NK-1 receptor antagonists have synergic effects and minimize the side-effects of these classic drugs. Thus, NK-1 receptor antagonists could offer a new and promising generation of anticancer drugs.
Keywords: Substance P, neoangiogenesis, metastasis, tumor cells, apoptosis, preprotachykinin A, in situ, malignant melanomas, gastric motility, SP-immunoreactivity, NK-1 receptors
Mini-Reviews in Medicinal Chemistry
Title:NK-1 Receptor Antagonists: A New Generation of Anticancer Drugs
Volume: 12 Issue: 7
Author(s): M. Munoz and R. Covenas
Affiliation:
Keywords: Substance P, neoangiogenesis, metastasis, tumor cells, apoptosis, preprotachykinin A, in situ, malignant melanomas, gastric motility, SP-immunoreactivity, NK-1 receptors
Abstract: After binding to the neurokinin-1 (NK-1) receptor, substance P (SP) induces tumor cell proliferation, angiogenesis, and the migration of tumor cells for invasion and metastasis. After binding to NK-1 receptors, NK-1 receptor antagonists inhibit tumor cell proliferation, angiogenesis and the migration of tumor cells. These antagonists are broad-spectrum antitumor drugs. In addition, in the host they display beneficial effects: anxiolytic, antiemetic, neuroprotector, nephroprotector, hepatoprotector, antiinflammatory and analgesic. In combination therapy with classic cytostatics, NK-1 receptor antagonists have synergic effects and minimize the side-effects of these classic drugs. Thus, NK-1 receptor antagonists could offer a new and promising generation of anticancer drugs.
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Cite this article as:
Munoz M. and Covenas R., NK-1 Receptor Antagonists: A New Generation of Anticancer Drugs, Mini-Reviews in Medicinal Chemistry 2012; 12 (7) . https://dx.doi.org/10.2174/138955712800626692
DOI https://dx.doi.org/10.2174/138955712800626692 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
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