Abstract
Parkinson's disease (PD), the most frequent movement disorder, is caused by the progressive loss of the dopamine neurons within the substantia nigra pars compacta and the associated deficiency of the neurotransmitter dopamine in the striatum. Most cases of PD are of a sporadic nature whose cause is unknown, while mutations in several genes have been linked to genetic forms of PD (α-synuclein, Parkin, DJ-1, PINK1, and LRRK2). Epidemiological studies in humans, as well as molecular studies in toxin-induced (e.g. 6-hydroxydopamine (6-OHDA) and rotenone) and genetic animal models of PD show that mitochondrial dysfunction, especially Complex I, is a defect occurring early in the pathogenesis of both sporadic and familial PD. Mitochondrial dynamics (fission, fusion, migration) are important for neurotransmission, synaptic maintenance and neuronal survival.....
CNS & Neurological Disorders - Drug Targets
Title:Commentary
Volume: 11 Issue: 3
Author(s): Stephen D. Skaper
Affiliation:
Abstract: Parkinson's disease (PD), the most frequent movement disorder, is caused by the progressive loss of the dopamine neurons within the substantia nigra pars compacta and the associated deficiency of the neurotransmitter dopamine in the striatum. Most cases of PD are of a sporadic nature whose cause is unknown, while mutations in several genes have been linked to genetic forms of PD (α-synuclein, Parkin, DJ-1, PINK1, and LRRK2). Epidemiological studies in humans, as well as molecular studies in toxin-induced (e.g. 6-hydroxydopamine (6-OHDA) and rotenone) and genetic animal models of PD show that mitochondrial dysfunction, especially Complex I, is a defect occurring early in the pathogenesis of both sporadic and familial PD. Mitochondrial dynamics (fission, fusion, migration) are important for neurotransmission, synaptic maintenance and neuronal survival.....
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Cite this article as:
D. Skaper Stephen, Commentary, CNS & Neurological Disorders - Drug Targets 2012; 11 (3) . https://dx.doi.org/10.2174/187152712800672391
DOI https://dx.doi.org/10.2174/187152712800672391 |
Print ISSN 1871-5273 |
Publisher Name Bentham Science Publisher |
Online ISSN 1996-3181 |
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