Abstract
Fever above 38C that occurs in patients with acute neurosurgical diseases appears to worsen secondary brain injury and ultimate neurologic outcomes. Laboratory investigations are quite clear regarding the adverse effects of fever in terms not only of functional outcomes, but also histologic and neurochemical injury. Several preliminary clinical studies also suggest worsened neurologic outcomes in patients who are febrile compared to those who are not. Unfortunately, however, a large prospective study of 428 patients with acute neurosurgical diseases has shown that fever is extraordinarily common during the first seven days after subarachnoid hemorrhage, stroke, and TBI. The ability to eliminate fever in most of these patients during the first five to seven days after their injury would seem desirable. Based on a phase-I trial, it appears that intravascular cooling is a promising new method for avoiding fever in the neurosurgical ICU.
Keywords: Hypothermia, Fever
Current Pharmaceutical Design
Title: Therapeutic Moderate Hypothermia and Fever
Volume: 7 Issue: 15
Author(s): D. W. Marion
Affiliation:
Keywords: Hypothermia, Fever
Abstract: Fever above 38C that occurs in patients with acute neurosurgical diseases appears to worsen secondary brain injury and ultimate neurologic outcomes. Laboratory investigations are quite clear regarding the adverse effects of fever in terms not only of functional outcomes, but also histologic and neurochemical injury. Several preliminary clinical studies also suggest worsened neurologic outcomes in patients who are febrile compared to those who are not. Unfortunately, however, a large prospective study of 428 patients with acute neurosurgical diseases has shown that fever is extraordinarily common during the first seven days after subarachnoid hemorrhage, stroke, and TBI. The ability to eliminate fever in most of these patients during the first five to seven days after their injury would seem desirable. Based on a phase-I trial, it appears that intravascular cooling is a promising new method for avoiding fever in the neurosurgical ICU.
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Cite this article as:
Marion W. D., Therapeutic Moderate Hypothermia and Fever, Current Pharmaceutical Design 2001; 7 (15) . https://dx.doi.org/10.2174/1381612013397302
DOI https://dx.doi.org/10.2174/1381612013397302 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
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