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Current Medicinal Chemistry


ISSN (Print): 0929-8673
ISSN (Online): 1875-533X

Candida Proteases and Their Inhibition Prospects for Antifungal Therapy

Author(s): K. Stewart and C. Abad-Zapatero

Volume 8, Issue 8, 2001

Page: [941 - 948] Pages: 8

DOI: 10.2174/0929867013372698

Price: $65


The rationale for inhibition of the secreted acid proteases (SAP) of Candida fungal species as a novel antifungal strategy is outlined. Enzyme structure-activity relationship data regarding the inhibitor A-70450 are described along with results from in vivo antifungal assays. Developments from protein X-ray crystallographic studies, SAP knock-out genetic studies, and the importance of these new results for drug discovery are reviewed. Finally, inhibition of the Candida SAP enzymes with HIV protease inhibitors and a proposed role in candidiasis of AIDS patients is discussed.

Keywords: Candida Proteases, Antifungal Therapy, secreted acid proteases (SAP), Candida fungal species, fluconazole, echinocandin B, amphotericin, HIV PROTEASE INHIBITORS

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