Abstract
Gene expression microarrays and gene expression databases provide new opportunities for the discovery of drug targets and for determination of a drugs mode of action. We review gene expression analysis methods and describe studies that have identified cell cycle genes using differential expression analysis and co-expression analysis. We present an example of the identification of previously-unrecognized human cell cycle genes, CDCA1 through CDCA8, that are co-expressed with known cell cycle genes including CDC2, CDC7, CDC23, cyclin, MCAK, mki67a, topoisomerase II, and others.
Keywords: Gene Expression Analysis, hepatitis B viral protein, Fisher Exact test, Bonferroni, papillomavirus, hypothetical genes
Current Cancer Drug Targets
Title: Drug Target Discovery by Gene Expression Analysis Cell Cycle Genes
Volume: 1 Issue: 1
Author(s): M. G. Walker
Affiliation:
Keywords: Gene Expression Analysis, hepatitis B viral protein, Fisher Exact test, Bonferroni, papillomavirus, hypothetical genes
Abstract: Gene expression microarrays and gene expression databases provide new opportunities for the discovery of drug targets and for determination of a drugs mode of action. We review gene expression analysis methods and describe studies that have identified cell cycle genes using differential expression analysis and co-expression analysis. We present an example of the identification of previously-unrecognized human cell cycle genes, CDCA1 through CDCA8, that are co-expressed with known cell cycle genes including CDC2, CDC7, CDC23, cyclin, MCAK, mki67a, topoisomerase II, and others.
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Cite this article as:
Walker G. M., Drug Target Discovery by Gene Expression Analysis Cell Cycle Genes, Current Cancer Drug Targets 2001; 1 (1) . https://dx.doi.org/10.2174/1568009013334241
DOI https://dx.doi.org/10.2174/1568009013334241 |
Print ISSN 1568-0096 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5576 |
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