Generic placeholder image

Current Molecular Medicine


ISSN (Print): 1566-5240
ISSN (Online): 1875-5666

Research Article

IL1R2 Polymorphisms are Associated with Increased Risk of Esophageal Cancer

Author(s): Jianfeng Liu*, Yonghui Yang*, Haiyue Li, Yuanwei Liu, Yao Sun, Jiamin Wu, Zichao Xiong and Tianbo Jin

Volume 20, Issue 5, 2020

Page: [379 - 387] Pages: 9

DOI: 10.2174/1566524019666191025091204

Price: $65


Background: Esophageal cancer (EC) is the sixth leading cause of cancer death worldwide, and the overall incidence is increasing.

Objective: The aim of this study was to evaluate the association between single nucleotide polymorphisms in IL1R2 and EC risk in the Chinese population.

Methods: Genotyping of six SNPs of IL1R2 was performed with the Agena MassARRAY platform from 384 EC and 499 controls. The association between polymorphisms and EC risk was assessed by performing genetics models and haplotype analyses.

Results: Overall analysis results showed that the allele C of rs11674595 (odds ratio [OR] = 1.42, 95% confidence interval [CI]: 1.14-1.77, p = 0.002) and allele G of rs2072472 (allele: OR = 1.35, 95% CI: 1.08-1.69, p = 0.008) were associated with an increased EC risk. The rs11674595 and rs2072472 were found to be correlated with EC risk under the codominant, dominant, and additive models. Stratification analysis found that rs11674595 and rs2072472 were associated with increased EC risk in male and in age > 55 years old subgroup. In addition, Crs11674595Grs4851527 haplotype was significantly associated with 1.44-fold increased risk of EC (95% CI: 1.12-1.84, p = 0.004).

Conclusion: Our results reveal the significant association between SNPs (rs11674595 and rs2072472) in the IL1R2 and EC risk in the Chinese Han population. The findings may provide meaningful reference for the prevention and treatment of EC.

Keywords: Esophageal cancer, IL1R2, polymorphism, case-control study, SNPs, tumorigenesis.

Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin 2018; 68(6): 394-424.
[] [PMID: 30207593]
Chen W, Zheng R, Baade PD, et al. Cancer statistics in China, 2015. CA Cancer J Clin 2016; 66(2): 115-32.
[] [PMID: 26808342]
Mao WM, Zheng WH, Ling ZQ. Epidemiologic risk factors for esophageal cancer development. Asian Pac J Cancer Prev 2011; 12(10): 2461-6.
[PMID: 22320939]
Zhang Y. Epidemiology of esophageal cancer. World J Gastroenterol 2013; 19(34): 5598-606.
[] [PMID: 24039351]
Geng TT, Xun XJ, Li S, et al. Association of colorectal cancer susceptibility variants with esophageal cancer in a Chinese population. World J Gastroenterol 2015; 21(22): 6898-904.
[] [PMID: 26078566]
An J, Zhao J, Zhang X, et al. Impact of multiple Alcohol Dehydrogenase gene polymorphisms on risk of laryngeal, esophageal, gastric and colorectal cancers in Chinese Han population. Am J Cancer Res 2015; 5(8): 2508-15.
[PMID: 26396927]
Wu Y, Yan M, Li J, et al. Genetic polymorphisms in TERT are associated with increased risk of esophageal cancer. Oncotarget 2017; 8(6): 10523-30.
[] [PMID: 28060765]
Wang J, Zhang B, Yang Z, et al. Association of gastrointestinal gland cancer susceptibility loci with esophageal carcinoma among the Chinese Han population: a case-control study. Tumour Biol 2016; 37(2): 1627-33.
[] [PMID: 26304507]
Wang H, Yu J, Guo Y, et al. Genetic variants in the ZNF208 gene are associated with esophageal cancer in a Chinese Han population. Oncotarget 2016; 7(52): 86829-35.
[] [PMID: 27907911]
Jia X, Liu P, Zhang M, et al. Genetic variants at 6p21, 10q23, 16q21 and 22q12 are associated with esophageal cancer risk in a Chinese Han population. Int J Clin Exp Med 2015; 8(10): 19381-7.
[PMID: 26770579]
Abnet CC, Wang Z, Song X, et al. Genotypic variants at 2q33 and risk of esophageal squamous cell carcinoma in China: a meta-analysis of genome-wide association studies. Hum Mol Genet 2012; 21(9): 2132-41.
[] [PMID: 22323360]
Wu C, Wang Z, Song X, et al. Joint analysis of three genome-wide association studies of esophageal squamous cell carcinoma in Chinese populations. Nat Genet 2014; 46(9): 1001-6.
[] [PMID: 25129146]
Gharahkhani P, Fitzgerald RC, Vaughan TL, et al. Genome-wide association studies in oesophageal adenocarcinoma and Barrett’s oesophagus: a large-scale meta-analysis. Lancet Oncol 2016; 17(10): 1363-73.
[] [PMID: 27527254]
Auron PE, Webb AC, Rosenwasser LJ, et al. Nucleotide sequence of human monocyte interleukin 1 precursor cDNA. Proc Natl Acad Sci USA 1984; 81(24): 7907-11.
[] [PMID: 6083565]
Apte RN, Dotan S, Elkabets M, et al. The involvement of IL-1 in tumorigenesis, tumor invasiveness, metastasis and tumor-host interactions. Cancer Metastasis Rev 2006; 25(3): 387-408.
[] [PMID: 17043764]
Mar AC, Chu CH, Lee HJ, et al. Interleukin-1 receptor type 2 acts with c-Fos to enhance the expression of interleukin-6 and vascular endothelial growth factor a in colon cancer cells and induce angiogenesis. J Biol Chem 2015; 290(36): 22212-24.
[] [PMID: 26209639]
Chun S, Kim H, Ku SY, Suh CS, Kim SH, Kim JG. The association between endometriosis and polymorphisms in the interleukin-1 family genes in Korean women. Am J Reprod Immunol 2012; 68(2): 154-63.
[] [PMID: 22509941]
Kamei H, Ishihara Y, Fuma D, et al. Interleukin-1 receptor gene variants are associated with aggressive periodontitis in the Japanese. Arch Oral Biol 2014; 59(7): 756-63.
[] [PMID: 24818754]
Xia Y, Liu YQ, Chen K, Wang LC, Ma CY, Zhao YR. Association of IL-1R2 genetic polymorphisms with the susceptibility of ankylosing spondylitis in Northern Chinese Han population. Mod Rheumatol 2015; 25(6): 908-12.
[] [PMID: 25736356]
Xie M, Zhang D, Zhang Y, et al. Association of genetic polymorphisms in IL-1R1 and IL-1R2 genes with IgA nephropathy in the Han Chinese population. Oncotarget 2017; 8(31): 50673-9.
[] [PMID: 28881593]
Gabriel S, Ziaugra L, Tabbaa D. SNP genotyping using the Sequenom MassARRAY iPLEX platform. Curr Protoc in Hum Gnet 2009; 60: 2-12.
Peters VA, Joesting JJ, Freund GG. IL-1 receptor 2 (IL-1R2) and its role in immune regulation. Brain Behav Immun 2013; 32(4): 1-8.
[] [PMID: 23195532]
Re F, Sironi M, Muzio M, et al. Inhibition of interleukin-1 responsiveness by type II receptor gene transfer: a surface “receptor” with anti-interleukin-1 function. J Exp Med 1996; 183(4): 1841-50.
[] [PMID: 8666940]
Sims JE, Dower SK. Interleukin-1 receptors. Eur Cytokine Netw 1994; 5(6): 539-46.
[PMID: 7727687]
Dinarello CA, Simon A, van der Meer JW. Treating inflammation by blocking interleukin-1 in a broad spectrum of diseases. Nat Rev Drug Discov 2012; 11(8): 633-52.
[] [PMID: 22850787]
Kondera-Anasz Z, Mielczarek-Palacz A, Switała J. [Significantly increased interleukin-1A and interleukin-1 soluble type II receptor levels in women with ovarian cancer]. Ginekol Pol 2003; 74(9): 761-6.
[PMID: 14674121]
Rückert F, Dawelbait G, Winter C, et al. Examination of apoptosis signaling in pancreatic cancer by computational signal transduction analysis. PLoS One 2010; 5(8) e12243
[] [PMID: 20808857]
Lin R, Zhang C, Zheng J, et al. Chronic inflammation-associated genomic instability paves the way for human esophageal carcinogenesis. Oncotarget 2016; 7(17): 24564-71.
[] [PMID: 27028857]
Na Y, Bai R, Zhao Z, Wang J, Wang Y, Zhang B, et al. IL1R2 polymorphisms and knee OA susceptibility in a Chinese Han population.
Zuo X, Li M, Yang Y, et al. Interleukin gene polymorphisms in Chinese Han population with breast cancer, a case-control study. Oncotarget 2017; 9(26): 17994-8001.
[PMID: 29719585]

Rights & Permissions Print Cite
© 2024 Bentham Science Publishers | Privacy Policy