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Current Pharmaceutical Design


ISSN (Print): 1381-6128
ISSN (Online): 1873-4286

Review Article

The Emerging Role of Exosomal Non-coding RNAs in Musculoskeletal Diseases

Author(s): Chao Tu, Jieyu He, Ruiqi Chen and Zhihong Li*

Volume 25, Issue 42, 2019

Page: [4523 - 4535] Pages: 13

DOI: 10.2174/1381612825666191113104946

Price: $65


Exosomes are phospholipid bilayer-enclosed membrane vesicles derived and constitutively secreted by various metabolically active cells. They are capable of mediating hetero- and homotypic intercellular communication by transferring multiple cargos from donor cells to recipient cells. Nowadays, non-coding RNAs (ncRNAs) have emerged as novel potential biomarkers or disease-targeting agents in a variety of diseases. However, the lack of effective delivery systems may impair their clinical application. Recently, accumulating evidence demonstrated that ncRNAs could be efficiently delivered to recipient cells using exosomes as a carrier, and therefore can exert a critical role in musculoskeletal diseases including osteoarthritis, rheumatoid arthritis, osteoporosis, muscular dystrophies, osteosarcoma and other diseases. Herein, we present an extensive review of biogenesis, physiological relevance and clinical implication of exosome-derived ncRNAs in musculoskeletal diseases.

Keywords: Exosome, lncRNA, miRNA, osteosarcoma, osteoarthritis, rheumatoid arthritis.

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