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Current Organic Chemistry


ISSN (Print): 1385-2728
ISSN (Online): 1875-5348

Review Article

The Chemical Structure and Bioactivity of Cycloartane-type Compounds

Author(s): Wenyan Gao , Xiaoyan Dong, Taiming Wei and Wenmin Xing*

Volume 23, Issue 25, 2019

Page: [2848 - 2872] Pages: 25

DOI: 10.2174/1385272823666191203113221

Price: $65


For decades now, compounds in the cycloartane-type series have been shown to have versatile pharmacological activities. However, no extensive review has been written to summarize these health-beneficial activities. Therefore, the purpose of this paper is to systematically highlight the biological activities of these compounds, including their antitumor and anti-osteoporosis effects, their effects on receptors, cytokine release, and chronic renal failure, as well as their tyrosinase inhibitory, anticomplement, anti-parasite, anti-HIV, and antituberculosis activities. In this review, we have summarized the structures of over 200 compounds based on their characteristics and described their structureactivity relationships (SARs), and potential mechanisms of action.

Keywords: Cycloartane, structure-activity relationships, tetracyclic triterpene, biological activities, antitumor effect, anti-inflammatory activity.

Graphical Abstract
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